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Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

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Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#71
post #56

Earlier quoted context omitted.

Out of curiosity, do you also drink Yakult or similar? https://en.wikipedia.org/wiki/Yakult

may i ask why?

Sure. Ozempic slows down stomach emptying, so food sits around longer in your stomach before continuing on the rest of the digestive process.

That seems like it could allow for some not-real-great bacteria to multiply, in an environment they're happy with.

Yakult would potentially head that off / stop those bacteria from doing that.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#72

Earlier quoted context omitted.

Even some pills cannot be split really easily. One example I like to give is Vyvanse. It uses extended release balls that are not evenly distributed in terms of what they contain (I’m no expert here, just going off a doctor’s summary). The only way to properly split it is to pour it into a glass of water and let it dissolve, then take the percentage of the dosage that you need and consume that percentage of water bef…

Letting it dissolve like that will interrupt the time release mechanism. This is not recommended

My understanding of Vyvanse is that it uses metabolic mechanisms in order to time the release of the drug which helps to prevent abuse. I'm far from a doctor however.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#73

Earlier quoted context omitted.

Letting it dissolve like that will interrupt the time release mechanism. This is not recommended

My understanding of Vyvanse is that it uses metabolic mechanisms in order to time the release of the drug which helps to prevent abuse. I'm far from a doctor however.

I’m not sure about vyvanse specifically but for some medications the time release mechanism is the coating. my comment should have been more clear

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#74

Earlier quoted context omitted.

All the non-diabetics using it will generate great data.. for the rest of us.

Unfortunately not really, because the infrastructure that allows us to glean insights from actual healthcare practices is abysmal/nonexistent, at least in the US. It became clear during COVID that a lot of people seem to presume there's some way for researchers to just "look at what's happening," and there isn't.

That's a really good point, and it seems to pervade the scientific establishment. There's an unfortunate tendency to study something, and (assuming a real effect is found & reproduced) say 'well we know about that now' and just move onto something else, instead of building out infrastructure to gather more longitudinal/geographic data. The efforts in the UK to build huge datasets for long-term diagnostics is a welcome exception.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#75
post #8

Earlier quoted context omitted.

We can! But should we? Being fat is similar to being a drug user. At first, you actually are fat and happy. Over time, being fat will absolutely reduce your happiness from the medical, societal, and physical issues that arise. Similar to how drug users build up a tolerance and instead of using the drug to be happy, they use the drug to feel normal. And just to state a simple fact, I do not condone shaming people with…

I have thought of this before. But it isn't really the same. Drugs, the really bad ones will probably ruin your life or kill you in the space of two or three years. Being fat unless it's super super severe often won't start impacting your health seriously until your 30's or 40's. on the opposite side anorexia will kill you much faster than obesity

Really bad drugs kill through overdose, whether from low quality supply or some users' inability to manage their addiction. I think there are more 'functional addicts' around than most realize. It seems to me that a good comparison to morbid obesity is tobacco smoking; you can keep at that for a long time but the odds of cumulative damage becoming disabling rise inexorably.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#76

Earlier quoted context omitted.

Yes, to a certain degree. But now we are in an obesity epidemic. It is just as bad as people smoking in the previous generations. Loads of people are MORBIDLY obese.

Good for them?

Why? Have you seen the medical outcomes for people in that group who develop acute medical problems? I don't mean just the statistical outcomes, but the qualitative individual ones. Other than 'possibly survive a sudden famine' I cannot think of a single thing morbid obesity makes better.

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#77

Earlier quoted context omitted.

Good for them?

Why? Have you seen the medical outcomes for people in that group who develop acute medical problems? I don't mean just the statistical outcomes, but the qualitative individual ones. Other than 'possibly survive a sudden famine' I cannot think of a single thing morbid obesity makes better.

Better than being stripped of their human agency and choice.

Better to be fat and happy than skinny with someone controlling your life

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#78

Earlier quoted context omitted.

Letting it dissolve like that will interrupt the time release mechanism. This is not recommended

My understanding of Vyvanse is that it uses metabolic mechanisms in order to time the release of the drug which helps to prevent abuse. I'm far from a doctor however.

vyvanse relies heavily on the second pass effect to activate, which is what makes it resistant to abuse. it also means if you don’t make sure to eat lunch the second half of the dose doesn’t kick in until supper and you end up being awake until 4-5am. ask me how i know…

Re: Ozempic linked to stomach paralysis, other gastrointestinal issues: UBC study

#79

Earlier quoted context omitted.

Why? Have you seen the medical outcomes for people in that group who develop acute medical problems? I don't mean just the statistical outcomes, but the qualitative individual ones. Other than 'possibly survive a sudden famine' I cannot think of a single thing morbid obesity makes better.

Better than being stripped of their human agency and choice. Better to be fat and happy than skinny with someone controlling your life

Being controlled by the corn/sugar industry doesn't sound great to me but you do you.
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