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Scientists regenerate hair cells that enable hearing

hms.harvard.edu

71–80 of 89 posts

Re: Scientists regenerate hair cells that enable hearing

#71
When I was younger I had a very expensive full blown audio system in my car. I would drive around blasting music so loud you'd feel it shaking your bones and punching your organs (don't worry it was a pretty rural area). A totally visceral experience.

I absolutely cannot do that anymore, given the damage it eventually did to my ears, but man, If I could heal my ears so I could go back and do that again...

Re: Scientists regenerate hair cells that enable hearing

#72
post #19

This is incidentally one of the low-key issues that happens to a lot of soldiers - however attentive you are, ultimately you're going to get exposed to some loud bangs even if you're never in an actual war zone. So there's a big demand for an effective way to restore damaged hearing.

And shooting enthusiasts. Decent ear pro significantly slows down the process, but it doesn't eliminate it. I'd love for my eye floaters and gradually-increasing tinnitus to be non-invasively curable (or at least treatable) before I die.

Re: Scientists regenerate hair cells that enable hearing

#73
post #36

Earlier quoted context omitted.

I’d love to know what silence is like.

Well, actually, true silence (as in an anechoic chamber) can be maddening.

Have you ever been in one? I visited the one that Norwegian Broadcasting Corporation (NRK) had at Marienlyst in Oslo. This is before I knew anything about anechoic chambers and the sort.

It was called The Dead Room...

The first thing I noticed is that I had to speak a lot louder to be heard. But the most unnerving thing happened when we finally stood still in there.

I could hear my blood run through my own veins.......... So out of sheer panic I started moving and talking again lol.

This room was in the basement, and was secluded from all the other rooms in the building. The control room was even two stories up from the studio. They used it to record special samples that had to be completely "dead," as in no echo or reverberation on it outside the instrument itself. By they looks of it they also used it for Foley recordings, because there was some surfaces in there and some pans of powders and sand.

Re: Scientists regenerate hair cells that enable hearing

#74
post #70

We are a long way from a cure. Hearing is complicated, this is a repost and it's believed many components need to be fixed in order to hear again. A drug (FX-322) was pulled recently after reaching stage 2 clinical trials and had good evidence of regenerating hair cells via progenitors in mice and cadaver. Hair cells are not even considered the first thing to be damaged when one notices hearing loss. It's considered…

The article seems to suggest that the SG cell is also getting regenerated. See > The new cells contained transduction channels that relay sound signals and the ability to form connections with auditory neurons — processes essential to hearing.

Are both cell types functional?

Re: Scientists regenerate hair cells that enable hearing

#76

Not obviously related to the article, but given this might attract the hearing-curious or knowledgeable. For as long as I can remember I've had great difficulty hearing in noisy environments. In my younger years it didn't bother me too much as I was mostly at noisy events to enjoy the music anywhere, and if I wanted to talk we'd move somewhere quieter. If I make a concerted effort I can usually hear someone directly…

I'm in the same situation. I was told that this is a relatively common symptom if you have ADHD and it's close to auditory processing disorder. Basically you just get deeply distracted by loud sounds and can't focus on anything auditory.

Re: Scientists regenerate hair cells that enable hearing

#77

We are a long way from a cure. Hearing is complicated, this is a repost and it's believed many components need to be fixed in order to hear again. A drug (FX-322) was pulled recently after reaching stage 2 clinical trials and had good evidence of regenerating hair cells via progenitors in mice and cadaver. Hair cells are not even considered the first thing to be damaged when one notices hearing loss. It's considered…

The web was weird and wonderful. The cure was Facebook and Twitter.

Keep your cure for JS as far away from me as possible, thanks.

Re: Scientists regenerate hair cells that enable hearing

#78

Earlier quoted context omitted.

Same. Doesn't bother me at all, it's just background noise, but it's not true silence.

I used to play in bands and go to a lot of concerts without earplugs (mistakes of youth). I’ve had tinnitus for almost 20 years, and I am so used to it now that it’s a non issue. That said, it drove me crazy in the beginning.

30+ years of midwest raves did me in. One sound system had 1MW bass bins - have been to some with ~40ft x ~15ft of bass bins. Only one ruptured ear drum in all of that time (Regis - didn't even seem that loud) - that's the ear that is the worst. Doesn't bother me, other than anxiety about potential neurological effects.

Re: Scientists regenerate hair cells that enable hearing

#79

Earlier quoted context omitted.

Some generators on https://mynoise.net/ have strong anecdotal evidence of at least temporary clearing of tinnitus. There's even https://mynoise.net/Albums/view.php?album=TinnitusRelief YMMV.

Be careful with these. My friend had to see a specialist after extended use of mynoise because it made his tinnitus much worse to the extent that it was almost intolerable.

Yeah, I tried them when they started and for me it didn't make my tinnitus worse, it just made me notice much more when it's there because suddenly I had breaks from it, and THAT was worse. I used them a few times and quit because of that.
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