Earlier quoted context omitted.
I imagine this should be possible with a very small connector addon that calls out to a secure wallet running on the desktop as a native application. This requires some careful consideration to prevent phishing and other nastiness, but a native application could use native window prompts and techniques such as Windows Hello/TouchID as an authentication technique that's hard to spoof. The complexity and risks are stil…
Crypto wallets also have access to the secure enclave via webauthn. I develop a new wallet (Portal) which will have webauthn but I know Glow uses Windows Hello right now.
I know it works through public/private key sharing but I wasn't aware that it provides such direct primitives.