Live data from Hacker News

Time-restricted eating reshapes gene expression throughout the body

sciencedaily.com

71–80 of 97 posts

Re: Time-restricted eating reshapes gene expression throughout the body

#72
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

[dead]

Re: Time-restricted eating reshapes gene expression throughout the body

#73
post #5
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

N=1 and also probably too many variables to learn from this - keto itself is already a massive lifestyle intervention. Did you restrict calories as well? Exercise?

I started IF only after I had been doing keto for about six weeks. At that point it was frankly easy because I wasn't getting hungry or having cravings anymore. I can't tease out how much IF contributed but I'd already lost a remarkable amount of weight on just keto. In general, I'd recommend only making one significant change at a time.

Calorie tracking and restriction pretty much comes with strict keto. Transitioning to keto rigorously requires detailed tracking of every molecule that goes in your mouth (with a food scale and measuring cups), at least for the first 12 weeks. I tracked constantly for about 6 mos until it was automatic for me and I knew every food and portion I typically encounter at a glance. It's hard at first but only tracking part way is the #1 reason for failing to get results.

I didn't do any exercise at all while losing weight, in fact while changing diet I was more sedentary than my usual slug-like activity level due to work and life factors. For me, exercise has always been hard, unpleasant and inevitably makes me hungrier. N=1 but that's what worked best for me and my weight loss was dramatic and super fast (>100 lbs in 8 mos).

Re: Time-restricted eating reshapes gene expression throughout the body

#74

For posters who do time restricted eating, how do you deal with the panicked/dizzy feeling you often get when not eating for long periods. Does that eventually go away with IF, or do you just get used to it?

Electrolytes.

You probably need at least more sodium.

https://old.reddit.com/r/fasting/wiki/fasting_in_a_nutshell/...

Re: Time-restricted eating reshapes gene expression throughout the body

#75
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

I think it was 15:9 and since it is in mice it's hard to say but I reckon thats the equivalent of more like 24+ hour fasts in humans.

Re: Time-restricted eating reshapes gene expression throughout the body

#76
post #25

A mouse only lives 5 years so if we scale everything based on this to humans you’d have to be fasting for 16h * (80 years / 5 years) = 256h or nearly 11 days. You could be damn sure doing this regularly your gene expression would change. Of course basing the scaling this way is completely ridiculous but no less ridiculous than inferring anything about humans from the original study.

I see where you're coming from, but just because mice don't live as long as humans doesn't mean all biological processes happen 16x as fast. They don't defecate 16x as often as humans or sleep 16x per day. Do you think there is 0 signal about potential impacts on humans from testing on mice? How would you prefer research be done with a similar cost, ability to control variables, & level of ethics?

Not 16x, but a 15 hour mouse fast definitely doesn't translate to diel IF type pattern in humans. There's a signal here sure but it probably corresponds to fasts of more than a day.

Re: Time-restricted eating reshapes gene expression throughout the body

#77
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

I have been doing similar for about 3 years now, with similar results, but one thing that has been problematic with for me... is my bowel movements just don't seem to function well when I'm doing keto. The only thing that seems to fix them is milk+cereal... (fiber from veggies don't seem to quite cut it). So I kind of alternate between periods of keto, and a normal diet. How do you do strict keto?

Re: Time-restricted eating reshapes gene expression throughout the body

#78
post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

It took me around 2 months to get adjusted to it. Also, I lost a lot of hair during the initial months. It is a big shock for body to get adjusted after a life long breakfast eating habit.

The advantage is that I no longer get hungry. Ever. If skip lunch I might feel weak by evening but never hungry. You develop this super power against food. You can choose what and when to eat and not give in to whatever is available.

Re: Time-restricted eating reshapes gene expression throughout the body

#79
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

How did you test your A1C?

They're available OTC, eg. https://www.walgreens.com/store/c/walgreens-at-home-a1c-test...

Re: Time-restricted eating reshapes gene expression throughout the body

#80

I tried this. Ended up thinking about food too much until 1 pm. But I might try it again.

Another approach that had some popularity a bit ago was "VB6" - Vegan Before Six (pm).

Mark Bittman's VB6 Diet - https://www.webmd.com/diet/a-z/mark-bittman-vb6-diet

Vegan by Day, Glutton by Night? Thinking About VB6 - https://www.bittmanproject.com/p/236239_vegan-by-day-glutton...

You can find other posts of people trying it.

Post reply on HN