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Australia gives world-first approval for fecal transplants to restore gut health

theguardian.com

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Re: Australia gives world-first approval for fecal transplants to restore gut health

#71

Post by cozos »

EarlKing wrote: post #40
GutThing wrote: post #26

I have a gut problem. I don't really know what it is. It's been like 4 or 5 years since it started. Doctors don't seem to know what's going on but basically my stomach acid destroys my throat and I can even feel the acidity in my mouth but I don't have heartburn or any other common symptoms. I've been on omeprazole and other PPI and several more drugs without any improvement. In all these years it stopped for around…

A number of studies have found a correlation between changes in the bacterial population of the distal esophagus and the onset of symptoms consistent with gastro-esophageal reflux disease and/or Barrett's Esophagus.[1][2][3][4] Your average practitioner doesn't necessarily keep up with trade journals, so it's unlikely most of them have any idea this is even a possibility. What likely happened is as follows: Taking an…

This is awesome! Do you happen to know anything about IBS-C that hasn't made it to medical practicioners?

Re: Australia gives world-first approval for fecal transplants to restore gut health

#72

Post by EarlKing »

cozos wrote: post #71
EarlKing wrote: post #40

Earlier quoted context omitted.

A number of studies have found a correlation between changes in the bacterial population of the distal esophagus and the onset of symptoms consistent with gastro-esophageal reflux disease and/or Barrett's Esophagus.[1][2][3][4] Your average practitioner doesn't necessarily keep up with trade journals, so it's unlikely most of them have any idea this is even a possibility. What likely happened is as follows: Taking an…

This is awesome! Do you happen to know anything about IBS-C that hasn't made it to medical practicioners?

Not really, no. Biology and medicine aren't really my field, and it's largely coincidence that I happen to know as much as I do about acid reflux disease.

Re: Australia gives world-first approval for fecal transplants to restore gut health

#74

Post by manmal »

cozos wrote: post #71
EarlKing wrote: post #40

Earlier quoted context omitted.

A number of studies have found a correlation between changes in the bacterial population of the distal esophagus and the onset of symptoms consistent with gastro-esophageal reflux disease and/or Barrett's Esophagus.[1][2][3][4] Your average practitioner doesn't necessarily keep up with trade journals, so it's unlikely most of them have any idea this is even a possibility. What likely happened is as follows: Taking an…

This is awesome! Do you happen to know anything about IBS-C that hasn't made it to medical practicioners?

Have you checked out butyrate? There are some sodium butyrate supplements on the market. And a Japanese probiotic with Clostridium butyricum which produces butyrate. Certain cells in the gut derive 70% of their energy (ATP) from butyrate. Butyrate deficiency => weak gut cells => inflammation + permeable gut lining.

„Protective Mechanisms of Butyrate on Inflammatory Bowel Disease“: https://pubmed.ncbi.nlm.nih.gov/30277149/

Re: Australia gives world-first approval for fecal transplants to restore gut health

#75

Post by ratsmack »

yetanotherloser wrote: post #44
throwaway5752 wrote: post #18

Earlier quoted context omitted.

I am not totally ignorant of this subject, but I'd be concerned about the unknowns involved in messing around with the very long term coevolution of gut biomes with particular diets, groups of people, and factors we might not know about yet. For one example, I don't believe that that gut viromes, the ecosystem of viruses that infect the gut biome bacteria, are very well understood. There is real wisdom in "do no harm…

I'm afraid I think the long term coevolution of gut biomes ship sailed around the time we started indiscriminately slaughtering those gut biomes with antibiotics. (not to mention importing large numbers of unfamiliar alternatives through changes in food systems, and at least in some cases raising kids in crazy-sterile environments). So I tend to agree with you that this doesn't seem like a good thing to rush into, bu…

The huge amounts of preservative used in our food chain has been even more devastating to our biome because we consume them continuously.

Re: Australia gives world-first approval for fecal transplants to restore gut health

#76

Post by stevenwoo »

stevenwoo wrote: post #52
LinuxBender wrote: post #2

Out of curiosity, how does this compare to mixing diverse cultures of probiotics with short chained fatty acids and injecting them rectally?

Not exactly your question, but my reading of The Gene: An Intimate History says any microbiome changes from eating fermented foods like yogurt/kefir/kimchi disappears when the food leaves ones diet. This was published in 2015 so could be superceded by subsequent studies in same field and I didn't bother researching the studies referenced in the book, either. The book also talks about successful uses of fecal matter t…

correction, the first note about fermented foods came from Burn(2022).

Re: Australia gives world-first approval for fecal transplants to restore gut health

#77

Post by cozos »

manmal wrote: post #74
cozos wrote: post #71

Earlier quoted context omitted.

This is awesome! Do you happen to know anything about IBS-C that hasn't made it to medical practicioners?

Have you checked out butyrate? There are some sodium butyrate supplements on the market. And a Japanese probiotic with Clostridium butyricum which produces butyrate. Certain cells in the gut derive 70% of their energy (ATP) from butyrate. Butyrate deficiency => weak gut cells => inflammation + permeable gut lining. „Protective Mechanisms of Butyrate on Inflammatory Bowel Disease“: https://pubmed.ncbi.nlm.nih.gov/3027…

I actually haven't heard about this, will definitely give it a shot, thanks! Where do you usually find information about this?

Re: Australia gives world-first approval for fecal transplants to restore gut health

#78

Post by GutThing »

rendaw wrote: post #68
samingrassia wrote: post #48

Earlier quoted context omitted.

What you are describing is LPR/respiratory reflux/silent reflux. It’s likely caused by diet, stress and posture that causes issues with the lower esophageal sphincter and unlikely to be bacterial overgrowth. Check this whole blog out if you can: https://jamiekoufman.com/silent-reflux-silent-night/

That's a fairly low quality med-spam internet article, like > so take the quiz below. If your total score is 15 or more, there’s a 90+% chance you have LPR reflux. with no quiz. It doesn't mention anything about posture, stress, or the lower esophageal. It seems like a new catch all stomach disease, much like the old catch all stomach disease. And despite this, you assert that it must be LPR?

I didn't find the quiz there but it looks like there's a standard test for LPR where if your score is 13-15 or above means you probably have it.

I've done it and being "reasonable" and not exaggerating on my answers, my score is 20, so it could be it. Symptoms are there and there's no heartburn or typical reflux.

In any case it looks like I'm doomed.

Re: Australia gives world-first approval for fecal transplants to restore gut health

#79

Post by manmal »

cozos wrote: post #77
manmal wrote: post #74

Earlier quoted context omitted.

Have you checked out butyrate? There are some sodium butyrate supplements on the market. And a Japanese probiotic with Clostridium butyricum which produces butyrate. Certain cells in the gut derive 70% of their energy (ATP) from butyrate. Butyrate deficiency => weak gut cells => inflammation + permeable gut lining. „Protective Mechanisms of Butyrate on Inflammatory Bowel Disease“: https://pubmed.ncbi.nlm.nih.gov/3027…

I actually haven't heard about this, will definitely give it a shot, thanks! Where do you usually find information about this?

IMO /r/microbiome is a great resource. Reddit in general, eg the nootropics subreddit is a treasure trove also. You could also search for „ameliorates [insert problem] pubmed“ or „[problem] [potential solution] pubmed“ in the search engine of your choice, and if an abstract piques your interest, view the full paper on sci-hub.

One thing I‘d like to stress is that the internet is full of scams and counterfeit products, and you can only be (pretty) sure a supplement is legit if you order it directly from the manufacturer. I think iHerb also has really good quality control, FWIW. Patented extracts are IME also preferable over run of the mill extracts, some of them are orders of magnitude more effective.

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