So, in a conventional reactor, you use nuclear fission to heat/pressurize water and then use your hot, slightly radioactive steam turn a turbine. This mostly works because moving even very hot, very high pressure water around is kind of a solved problem in industry. In a molten salt reactor, you use nuclear fission to melt various corrosive salts into a fluid, and this is good because molten salts store a lot more en…
See here for a (somewhat old) list of some technical issues:
https://gain.inl.gov/SiteAssets/MoltenSaltReactor/Module2-Ov...
"Nickel-based alloys embrittle under high neutron fluxes at high temperature"
"Over 40% of [fission products] leave core [in offgas]"
"Large fraction of cesium, strontium, and iodine end up in offgas"
"MSRE was approaching end of allowable service life when shut down" (after four years at 40% capacity factor)