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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

71–80 of 170 posts

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#71

Isn't it weird how we were created by a supposedly "dumb" universe but yet we can't find the cheat code?

Quite the opposite, I think?

Because the process is ‘dumb’ (as you put it) we evolved via chaos rather than order. It therefore follows that how we work is complex and disordered - and an easy ‘cheat code’ doesn’t exist.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#72
post #16
post #6

This article is a bit old (like the other comment about missing year tag says). I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues. https://www.science.org/content/article/bodybuilding-supplem...

The actual paper is here [1]. And it’s not quite as conclusive in mammals yet. But it sounds like there is a clinical trial to actually study the supplement, which is a welcome thing in the anti-aging world. I’m happy to read that this work came out of the Buck Institute in Novato, which is a solid research institution. It’s also a beautiful campus. Disclaimer: I was there for a short stint as a postdoc a while back…

[deleted]

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#73

Earlier quoted context omitted.

We've got to be careful or we're going to end up with super-intelligent immortal mice!

Super intelligent, immortal, and free of cancer, diabetes, Alzheimer, and MS.

And with a single giant ear on their back. Don’t forget the giant ear.

(Weirdly, just saw a breathless article talking about how 3D bioprinting obviates the use of rib cartilage that the human-ear-on-a-mouse 25 years ago was also supposed to end).

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#74

Earlier quoted context omitted.

Anti-aging effects in mice*

We've got to be careful or we're going to end up with super-intelligent immortal mice!

No post body was provided.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#75

It was a great validation, that reversing epigenetics is possible in the human body, but using Yamanaka factors to do the same thing has much more investment dollars behind it (billions vs millions), so I believe it will be ready on the market faster.

If money was what it took to be correct in medicine, Theranos would be a huge success.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#77

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

Depends on how you'd define 'immortality' in your though experiment.

I'd actually disagree with you - under the premise, you'd be able to end your life as you will.

In that case, hell yes, I'm in for that. I'm in my mid 20s and the past years have been filled with burn-out, depression and literal still stand career-/ education- wise. I can now really grasp how short life actually is. It's so easy (I did it!) to actually waste a notable portion of your life span.We're talking more than half a decade. It gives me shivers. I have so many interests and I'm never bored. I can find interesting topics in any domain and if I could, I'd stay in university my whole life. So, to make this short, I'd be the ultimate dream of mine to not have to care about what to fill my life with. It steamrolls me and I get a lot of fear out of it. But not the fear that drives you, the fear that paralyzes.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#78

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

I like to look at it holistically. If you don't want to live forever, your life is a rounding error anyway. May as well die today. Don't want to do that? Why do you imagine you want to do that in ten years?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#79

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

One thing I rarely see mentioned in regards to living forever is that during a life you will accumulate mental scars. My wife has lost a sister, and she's witnessed a murder. Neither she nor I are the same after those experiences. I don't think we will ever be. If we lived forever I think we would all become more and more anxious and excentric as time progressed and our souls inevitably became more "scarred". Maybe i…

> eccentric

This is good. I always say rich people can't be weird, only eccentric. And chances are if you live for a long time, you have more money :)

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#80

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

Altered Carbon, and to a lesser extend Upload! touch on this dystopian part - the great leveller is that every billionaire will one day die - imagine if that wasn't the case, and they could keep hoarding wealth and having undue political influence.

If you take a step back you see that when they currently die, someone with roughly their money takes over. Good families keep generational wealth, so you will always be under the influence of some rich person. It is our modern royalty after all.

Given that is the case and everything else being equal, I would prefer that exact scenario with an opportunity to live forever. Even if that means someone I don't like gets to try that too.

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