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Diluting blood plasma rejuvenates tissue, reverses aging in mice

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Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#71

Post by gojomo »

tropheusduboisi wrote: post #64
thimkerbell wrote: post #6

Implications for recruiting plasma donors?

No plasma donors. Old plasma is replaced with saline and albumin.

In this study, 50% of a body's old plasma is replaced with saline & albumin.

In plasma donation – which can be done in return for cash compensation in the USA! – 20% of a body's plasma is replaced with saline solution (no albumin).

Plasma donation might plausibly approximate this study's effects, at a lesser level.

Generally plasma donation is allowed every 28 days, though in some cases 3 donations over 8 weeks (or about once every 12 days) is allowed.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#72

Post by MiguelHudnandez »

hanniabu wrote: post #70
macrolime wrote: post #38

Earlier quoted context omitted.

study shows that people, who donate a lot of blood, suffer no serious ill effects and may even live longer than less frequent donors. https://sciencenordic.com/body-death-denmark/frequent-blood-...

Unfortunately they don't give any details on what constitutes more frequent and less frequent. For example once a month vs once a year or once very 2 weeks vs once every 2 years, etc.

Whole blood donation generally is only allowed every 8 weeks. Double-red blood cell donation is allowed every 16 weeks up to a maximum amount per 12-month period. I believe Plasma can be safely donated every 4 weeks. Doesn't tell you specifics about the study, but know there are different kinds of blood donation and different frequencies that are permitted for each.

I think it's common for regular donors to donate almost as often as is recommended.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#73

Post by simonsarris »

derefr wrote: post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

I don't know but since I was young it always seemed intuitive that blood-letting ought to have some good effects. If xyz bad things buildup (say, heavy metals) exist in the blood stream, and you remove a few % of your blood stream to make new blood, haven't you removed some xyz bad buildup?

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#74

Post by adityapurwa »

greggman3 wrote: post #69

Maybe I should get some pet leeches. I don't know if Google's search results are accurate but I watched The African Queen recently and when Bogart gets leeches I googled if they are harmful and the first results said "No"

There are various blood removal method, one of method that I’ve seen and commonly used is Hijamaz/Bekam. A small incision is made on the skin (usually the back); then a suction cup is used to draw the blood out. It is widely popular in Asia, I usually see it done by Moslem as they are recommended by their prophet to do so. Make sure the method is correct and that the equipment is sterile though.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#75

Post by throwaway_jobs »

derefr wrote: post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

> A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work, for a while; but it wasn't heavily optimized for.

I think your/the hypothesis fails...take certain species of jellyfish that are biologically immortal, they don’t have blood at all.

Coincidentally they are considered top of the food chain, so another knock to the hypothesis.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#76

Post by donclark »

What no one has yet discussed is being a plasma donor to keep the bad proteins down that have accumulated over time. You can donate 1 pint plasma up to twice a week, they replace it with saline and return the red cells to you. If someone went weekly, say, they would sooner or later have removed all the old plasma by dilution with the new plasma that replaces it - I dont have any data on how many donations it would take to remove 95% of the old plasma. No albumin is needed since you are only removing 1 unit and the body can replace it quickly, not like removing half the blood volume at once. Plus, they pay you to donate. - Jay Caplan

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#77

Post by phyzome »

aomix wrote: post #28
ASalazarMX wrote: post #24

Earlier quoted context omitted.

> "They replace half the blood volume in mice" I'd speculate the difference in volume is too great, having half your blood replaced with saline solution must feel awful.

Not really the same thing but I'm blood type O- and do the "Power Red" donation at Red Cross events. I have two units of blood taken out and the red cells and plasma are separated so the plasma can be returned along with saline to make up the difference in volume. I don't notice much of a difference besides feeling a little cold since the saline is at room temperature. However in that case I believe I'd only have ~10…

« I don't notice much of a difference besides feeling a little cold since the saline is at room temperature. »

I've always wondered: Why don't they warm it up?!

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#78

Post by dundarious »

naasking wrote: post #30
kgin wrote: post #20

The implication is not that young blood has specific positive properties, but that old blood has specific negative properties. Simply removing some of the "bad old blood" is already enough to measurably improve biomarkers. Identifying the bad stuff may go a long way to counteracting it in a more targeted way.

> Simply removing some of the "bad old blood" is already enough to measurably improve biomarkers. God damn it, those blood letters were onto something!

Haha, yes. Probably not a great idea to start blood-letting while fighting an infection, but as a prophylactic, it looks promising.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#79

Post by peterwoerner »

throwaway_jobs wrote: post #75
derefr wrote: post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

> A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work, for a while; but it wasn't heavily optimized for. I think your/the hypothesis fails...take certain species of jellyfish that are biologically immortal, they don’t have blood at all. Coincidentally they are considered top of the food chain, so another knock to the hypothe…

I think she/he/it was referring more specifically to mammals and other animals with blood.

Re: Diluting blood plasma rejuvenates tissue, reverses aging in mice

#80

Post by bloaf »

derefr wrote: post #57

Post-hoc "evolutionary just-so story" of the day: animals evolved under conditions of predation, where they'd tend to lose blood regularly, either in the process of fighting off/getting away from predators, or in the process of attacking prey with violent defenses. A species that goes years without losing any blood, is effectively operating its body in an evolutionary out-of-spec configuration. It might work , for a…

A testable hypothesis for your idea: do women age slower than men.
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