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The human genome is full of viruses

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71–80 of 118 posts

Re: The human genome is full of viruses

#71
post #3

I've always thought of DNA as mere "data". "This goes here, that goes there", etc. And I've always wondered how such a relatively small amount of data could describe the massive complexity of a full-size organism. But this makes it sound like DNA is data the way Lisp is data: it can contain procedures and transformations and meta-statements about itself, and even mutate during the course of being interpreted. That wo…

Yes, DNA is a programming language and ribosomes are the interpreter.

Re: The human genome is full of viruses

#72
post #68

Another fascinating fact is that about 20% of cancers are directly caused by viruses -- they push the cells they infect to be more cancer-like. The famous example is HPV, but there are many more.

And some by bacteria. Helicobacter pylori for example

Re: The human genome is full of viruses

#73

Earlier quoted context omitted.

In addition, only retroviruses are capable of altering DNA in such a manner. The common cold is not a retrovirus.

Sometimes it is, it depends on the virus causing it.

Do you have any examples of retroviruses that cause the common cold? I did a quick search but couldn't find anything, but that sounds like something that would be really interesting to read up on - the classical retrovirus isn't necessarily something that can go away after a couple days of sniffles and I'm curious to know if there are long term consequences to colds caused by retroviruses.

Re: The human genome is full of viruses

#74

> Even after recovering from an infection there will always be a piece of that virus encoded within your DNA. I did a little research and this appears to be almost completely false . This sentence makes it sound like every time you get a cold, your body's DNA is permanently altered. Which would be insane if true. The reality is that this insane outcome is incredibly rare, but nevertheless has happened enough times ov…

The article is rather fancifully written (and by a non-scientist) but as a professional genomicist, I can assure you that the human genome is full of viruses, the remnants of which are almost entirely non-functional, but are interesting in the way meteor craters are to geology.

Here is a review (nearly twenty years old from when the human genome was first sequenced) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138943/

Re: The human genome is full of viruses

#75
Train of thought while reading title and comments:

First: Genome cannot physically contain a bio-virus, so this must be genetic code, acting as a "computer virus"

Second: Oh they're talking about viral genome embedded in human genome. Got it.

Third: But wait, bio-virus genome embedded in human genome does not by-definition imply that there is something wrong with that human genome. It could just be an innocuous part of the viral genome.

Fourth: Parts of human genome that could act as "computer virus" (i.e., be malicious to the human), and parts of human genome that come from a bio-virus may have some overlap. But you could have two other options too: (a) part of human genome that is malicious but not from a bio-viral source, (b) part of human genome that is from a bio-virus but is not malicious.

Re: The human genome is full of viruses

#76
post #59

> Even after recovering from an infection there will always be a piece of that virus encoded within your DNA. I did a little research and this appears to be almost completely false . This sentence makes it sound like every time you get a cold, your body's DNA is permanently altered. Which would be insane if true. The reality is that this insane outcome is incredibly rare, but nevertheless has happened enough times ov…

> Viruses [...]have circadian rhythms like all living things. > circadian adj. of, relating to, or showing rhythmic behaviour with a period of 24 hours; especially of a biological process No, they don't. And the rest of the paragraph is equally goofy.

The circadian rythm thing is so egregiously absurd that it's easy to overlook the other spectacular claim in that sentence. Some people could argue that viruses are alive, but that's far from the mainstream interpretation and to say that the statement is wading into some potentially really be controversial territory is an understatement.

Re: The human genome is full of viruses

#77

> Even after recovering from an infection there will always be a piece of that virus encoded within your DNA. I did a little research and this appears to be almost completely false . This sentence makes it sound like every time you get a cold, your body's DNA is permanently altered. Which would be insane if true. The reality is that this insane outcome is incredibly rare, but nevertheless has happened enough times ov…

yes. that is completely false. now I'm doubting the whole article.

There's also some stuff about circadian rythms in there that makes no sense - the main point of the article that our genome has viral dna in it is true and really cool, the details of the article are kind of fantasy though. If you're interested in learning more probably better to do your own research or read through the wiki or something rather than sift through this article which, while an admirable attempt by a non-scientist to explore an interesting phenomenon, is not a very successful attempt.

Re: The human genome is full of viruses

#78
post #7
post #4

There was an interesting article a while back on them playing a part in schizophrenia. "The Insanity Virus" https://www.discovermagazine.com/mind/the-insanity-virus

What a great read! I find it so crazy that after decades of thinking that there's all this "junk DNA" in us, it turns out that it may serve a purpose after all, even if that purpose is malicious.

I don't know if junk DNA was ever universally considered to be "junk" - it's been controversial terminology from the start which has proven to be justified with time as we learn more about what it does.

Re: The human genome is full of viruses

#79
post #52

And the most fascinated fact is that, despite of all these intruders and mutators, living organisms are damn stable and pretty effective devices.

I mean, not that stable - the instability is kind of what allows evolution to happen. It's, well, it's good enough, stable enough, effective enough, and that's enough for life.

Re: The human genome is full of viruses

#80

Now I’m more convinced Evolution might be driven by viruses

Evolution is driven by a lot of things. It's driven by viruses by definition since of a virus integrates and makes a mutation to the germline, then that's a change which is evolution. And obviously bdosease is a major selective pressure driving evolution. And so so starvation, radiation, chemical mutation, errors in copying, heat, cold, literally everything that impacts survival and procreation drives evolution.
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