Earlier quoted context omitted.
I was using clean LineageOS for over 2 years, recently switching to LineageOS+microG. I'm using APKPure and F-Droid for apps, Chrome for browsing (as in Firefox, last time I checked, one tap separates you from losing all open tabs). Some apps refuse to work or break (e.g. Bitwarden does not sync), some have degraded functionality (e.g. WhatsApp sometimes does not ring when someone is calling you), many are just spamm…
I’m surprised Chrome runs without Google Play Services.
The only big inconvenience is getting bookmarks to PC. There is XML file in /data/data/com.android.chrome called Bookmarks (by the way, Chrome seems to be the only Google app in com.android namespace). I just use regex to select the lines with URLs.