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Nicotinamide riboside effects on aging similar to caloric restriction

colorado.edu

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Re: Nicotinamide riboside effects on aging similar to caloric restriction

#71

Post by nopinsight »

naasking wrote: post #64
dmix wrote: post #48

Earlier quoted context omitted.

From the article: > From a public health perspective [restricting calories] would be impractical for many and dangerous for some. Regardless of what's the most optimal solution it's very helpful to have the option when this isn't an easy/practical option. And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my…

For whom would calorie restriction be dangerous? I don't get the time and monetary cost either. You can precook your meals for a whole week on Sunday night, as long as you don't mind a little repetition.

For the elderly and perhaps others also, too little insulation means a higher chance of accidents (falls etc.) turning fatal.

It might be quite hard to consume a sufficient amount of certain nutrients like Calcium on caloric restricted diet as well.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#72

Post by jackhack »

klipt wrote: post #69
delbel wrote: post #43

Earlier quoted context omitted.

Smoking cigarettes would do it. Nicotine + Oxygen right? Who knew the movie Sleeper had it right, keto diet and tabacco. https://www.youtube.com/watch?v=D2fYguIX17Q

Smoking certainly reduces your chance of dying of old age. Mostly by increasing your chance of dying of lung cancer.

Perhaps an argument for "vaping," then? (Nicotine without the smoke and tar and other nasty compounds in tobacco.)

I never thought I would say that.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#73

Post by loeg »

nothrabannosir wrote: post #70
loeg wrote: post #61

Earlier quoted context omitted.

I'd take 5 extra QALYs any day.

Ironically, the Q stands for Quality. If the reports on calorie restricted diets are to be believed, that’s not an appropriate descriptor anymore.

Not ironic — that is exactly why I said QALYs and not just years.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#74

Post by JamesBarney »

gwern wrote: post #58
pwnage12 wrote: post #56

Earlier quoted context omitted.

Compliance for CR is near impossible though. I'm a believer in it but am still 10 pounds overweight. It won't work for everyone, obviously (because so many of us are overweight).

It's not impossible. Look at the CR experiments like CALERIE. Dropout is something like 10-20%, similar to intermittent fasting or other kinds of diets.

I'd heard CALORIE was selective with applicants in order to increase compliance.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#75

Post by JoshMnem »

dmix wrote: post #48
JoshMnem wrote: post #38

I think calorie restriction is a more interesting idea, because it forces you to think about eating high-nutrient foods. The first things I did were to eliminate sugars and other processed ingredients, including all flours. Continuing to eat junk and assuming that pills and supplements will compensate for that is probably not a good idea.

From the article: > From a public health perspective [restricting calories] would be impractical for many and dangerous for some. Regardless of what's the most optimal solution it's very helpful to have the option when this isn't an easy/practical option. And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my…

> And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my own meals, and buy fast-expiring produce.

I've been doing it for two years, and there are solutions to those problems. It's cheaper and faster to eat healthily and restrict calories than to cook a typical US diet -- it just requires a different perspective.

I wish I weren't busy at the moment, so I could build a website about how to manage it.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#76

Post by arnoooooo »

pwnage12 wrote: post #56
JoshMnem wrote: post #38

I think calorie restriction is a more interesting idea, because it forces you to think about eating high-nutrient foods. The first things I did were to eliminate sugars and other processed ingredients, including all flours. Continuing to eat junk and assuming that pills and supplements will compensate for that is probably not a good idea.

Compliance for CR is near impossible though. I'm a believer in it but am still 10 pounds overweight. It won't work for everyone, obviously (because so many of us are overweight).

Intermittent fasting is not that hard.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#77

Post by amelius »

e9 wrote: post #62
amelius wrote: post #59

Earlier quoted context omitted.

I've been taking Niagen for a couple of months, and I can say that for me it feels much better than niacin or niacinamide. I don't know why (perhaps I have some niacin metabolism problem, or the niacin interferes with some other impaired process such as the methylation cycle). Also there seems to be some synergy between Niagen and resveratrol and pterostilbene that I can clearly notice. Foods that work well with Niag…

That's interesting. Glad that you are experimenting! Everyone is so different that experimenting is the only way to find out what works and what doesn't for anyone :). Just curious, what other supplements did you find working out for you?

When a doctor's visit leads to a dead end, then yes, I believe experimenting is probably the only option left.

I've taken a lot of supplements in the past, but at some point I found out that stomach acid and digestion were the problem.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#78

Post by mistermann »

VoiceOfWisdom wrote: post #50
truculation wrote: post #41

Earlier quoted context omitted.

Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour. https://niacinreviews.com/niacin-max-flush/

Beware the niacin flush. Once I took 500mg, after having already been accustomed to the flush. It hit hard that day though. 15 minutes after taking the pill, while driving, my vision started to narrow and go black. It felt like being chocked out. I was rapidly losing consciousness, but was able to safely pull over to the side of the road. Before completely passing out I was able to vomit up what was left of the pill.…

FWIW, and not sure if this only helps the itching part of the side effect....

https://www.leaf.tv/articles/how-to-relieve-an-itch-from-nia...

Drink plenty of water. According to Dr. William Davis, a cardiologist from Wisconsin, ingest 2 8-oz. glasses of water immediately after the itching sensation begins. According to Dr. Davis, this quick task relieves the flush and itching symptoms in more than 90 percent of instances.

Take a 325mg table of uncoated aspirin; according to Dr. Davis, this can also alleviate the itching and burning.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#79

Post by mistermann »

JoshMnem wrote: post #75
dmix wrote: post #48

Earlier quoted context omitted.

From the article: > From a public health perspective [restricting calories] would be impractical for many and dangerous for some. Regardless of what's the most optimal solution it's very helpful to have the option when this isn't an easy/practical option. And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my…

> And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my own meals, and buy fast-expiring produce. I've been doing it for two years, and there are solutions to those problems. It's cheaper and faster to eat healthily and restrict calories than to cook a typical US diet -- it just requires a different perspecti…

I'd love to read even some high level bullet points of avenues to investigate, if that form is possible.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#80

Post by nothrabannosir »

loeg wrote: post #73
nothrabannosir wrote: post #70

Earlier quoted context omitted.

Ironically, the Q stands for Quality. If the reports on calorie restricted diets are to be believed, that’s not an appropriate descriptor anymore.

Not ironic — that is exactly why I said QALYs and not just years.

Unless I misunderstand QALY, wouldn't n+5 years of misery not necessarily equal n years of actual quality life? assuming a base quality of 0 k ≤ 1 with n years, and a calorie restricted life at quality 0 k' k with n+5, surely you'd end up at k * n QALYs for a normal life, and k' * (n + 5) for a calorie restricted one? Which might very well be lower given how large n is and how much smaller k' is than k.

Concretely: 85 years of misery is not 5 QALYs more than 80y of normal life.

Or am I missing your point, here?

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