Everytime I use clojure for some new project because I think it will help, I end up spending too much time on tooling and setup, and in the end change it to something easier to setup, which strangely that's javascript sometimes. I want to go work in a team where they have it ready for me and I can learn the tooling on the way, without needing to do that up front..
All you need for setting up a Clojure web project is a copy of the JDK and Leiningen. With that in place you just do:
lein new luminus myapp
and you're good to go. This will create a new instance of the Luminus (http://www.luminusweb.net/) tempalte that sets up all the boilerplate with reasonable defaults.