Pretty amazing that materials science (lighter, carbon-fiber aircraft; hotter, more efficient/powerful turbines) has made this economic. Concorde never was. NYC-LON seems like the one market where this enables something fundamentally new (well, Concorde did); single-day business trips between two major business centers which were otherwise a full day apart. Transpacific flights would be nice, too, but cutting an alre…
If they could make it quiet enough to go over land, transcontinental US flights would be great; LA/NY in 2.5 hours would likely have a pretty high demand. [edit] As someone who flies LA/DC fairly regularly I do have to mention my favorite record of the SR-71 doing that flight in under 65 minutes.
So, I think that high-altitude sparse-population daytime routes could be developed that would admit supersonic flight over much of North America.