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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#691

Post by rpunkfu »

ap99 wrote: post #503

This, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (…

I believe that while your points are valid, they play a much more important role than merely serving as a tool for someone who doesn't want to delve deeper into the problem.

I don't think being on Ozempic for an extended period is a good idea. This isn't because it's unhealthy, but because people often become leaner while still consuming unhealthy food. The difference is that they now exclusively eatthat unhealthy food, in good case bit less of it (based on my observations of people I know who are using it).

However, there is a significant benefit to Ozempic. For individuals struggling with self-control and obesity, it can help them reach a better starting point quickly. When someone is obese, every day matters. The sooner they lose weight, the more likely they are to feel motivated to take the next steps: moving more, exercising, and avoiding unhealthy food, as they won't want to waste the hard work they put into their workouts.

Re: Ozempic shows anti-aging effects in trial

#692

Post by ap99 »

radu_floricica wrote: post #390
leoh wrote: post #209

Earlier quoted context omitted.

True enough, but many studies show that calorie restriction reduces effects of aging

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Statins negatively affect mitochondria.

Re: Ozempic shows anti-aging effects in trial

#693

Post by ap99 »

cm2187 wrote: post #57
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. RFK Jr's "let them eat less" is paradoxically the modern version of "let them eat cake"!

Doesn't ozempic just make you eat less because you're less hungry?

Re: Ozempic shows anti-aging effects in trial

#694

Post by koliber »

I'm curious how they measured the biological age. My trainer has a scale that measures biological age and it seems very correlated with weight. When I weight less I am biologically younger, and vice versa. Ozempic does a good job at aiding weight loss, so I am wondering if this is a large contributor to the effect they saw.

Re: Ozempic shows anti-aging effects in trial

#695

Post by koliber »

kjkjadksj wrote: post #26
pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

People who lose a lot of fat generally end up with loose skin, regardless of the mechanism they use to lose the fat.

Re: Ozempic shows anti-aging effects in trial

#697

Post by koliber »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was one of them, and changed my mind. Ozempic seemed like too much of a wonder drug. Being conditioned that some things just seem too good to be true I avoided it for many years. But as the number of years passed and the amount of evidence of ill effects remained steady, the scale flipped and I got enough assurance that it's not just brilliant marketing or malicious evidence hiding. I guess that I would like to define myself as "cautiously optimistic" but in the back of my mind it seemed like there was something there that was not being revealed.

I've been taking it for a few months now and it really does seem like a wonder drug. All the benefits I needed without any noticeable drawbacks. It's weirdly good.

Re: Ozempic shows anti-aging effects in trial

#698

Post by 42772827 »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them?

Evolution favored this level of GLP1, then we invented agriculture, and cooking, and bliss points. Now it’s far easier to ingest massive numbers of calories in ways that our old world systems can’t properly signal against. Evolution hasn’t caught up and maybe never will.

Re: Ozempic shows anti-aging effects in trial

#699

Post by JumpCrisscross »

kjkjadksj wrote: post #26
pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

> lose all that buccal fat that defines your young adult face

The people who should be taking Ozempic aren't lacking in buccal fat.

Re: Ozempic shows anti-aging effects in trial

#700

Post by loeg »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> "No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1?

We can do science and technology on timescales vastly faster than evolution. "Why didn't evolution do it?" is just a very irrelevant question.

> The second point I haven't seen discussed is that weight loss drugs prior to GLP-1 agonists include cigarettes, which (worst case) give you cancer; stimulants, which cause your heart to fail; parasitic intestinal worms, which can kill you but more importantly are just plain gross; and mitochondrial uncouplers, which set you on fire at a cellular level. That's a long history of miracle weight loss drugs which turn out to have horrible side effects.

Cigarettes, parasitic worms, and 2,4-DNP were never medications.

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