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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#671

Post by Damogran6 »

BigJ1211 wrote: post #556
skeezyboy wrote: post #508

Earlier quoted context omitted.

> when we use technology to reoptimise our bodies to calorie abundance replace "calorie abundance" with "sedentary lifestyle" and youre there. its people eating more than they burn off because they dont exert themselves because thats what being an adult means.

Calorie abundance is accurate too, food has never been as cheap and delicious as it is now. Not to mention the ultra-processed high-density foods we have now. Meaning you can easily overeat with an active lifestyle too. In fact we have entire sports in which it's beneficial to do so. (Rugby/American Football, Strongman competitions and Sumo wrestling to name a few obvious ones)

Not just delicious...dangerously, addictively, delicious.

I don't by Doritos because for me, any size bag is one serving.

On Zepbound and it's stunning how my favorite beer...the one I craved and tasted so good 'why don't I have another?'...no longer has a hold on me. I could take two or three sips, set it down, and walk away.

I also now feel full, but not disgustingly over-stuffed now.

Re: Ozempic shows anti-aging effects in trial

#672

Post by ap99 »

shlant wrote: post #661
a5c11 wrote: post #566

Earlier quoted context omitted.

You don't quite understand the meaning of "symptom" and "illness", do you? Obesity - symptom. Usually the illness is a bad diet, lack of movement, or very rarely some serious health condition. Instead of targeting obesity, fix your habits or see a doctor to see why your body accumulates excessive amounts of fat. Dopamine issues, lack of concentration, etc. - symptoms. The illness is ADHD. By taking medicines you are…

wow people can just not be obese if they fix their habits! what a revelation! Better go tell all the obese people that, they surely have no idea.

Two things get in most people's way: nutritional knowledge and emotional control.

Health and age is a factor for some ofc but can you honestly say that people know the nutritional value of what they're eating and also can emotionally control when they eat?

Re: Ozempic shows anti-aging effects in trial

#673

Post by rybosworld »

radu_floricica wrote: post #390
leoh wrote: post #209

Earlier quoted context omitted.

True enough, but many studies show that calorie restriction reduces effects of aging

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Can you say more about Ibuprofen? I've understood it's fairly dangerous in some contexts. Especially for folks with compromised liver function.

Re: Ozempic shows anti-aging effects in trial

#674

Post by pooloo »

kion wrote: post #108
smiley1437 wrote: post #65

Earlier quoted context omitted.

Tirzepatide (and likely other GLPs) have limitations that are rarely brought up in the general media - Patients have about 72 weeks to reach maximum loss, they don't lose any more weight after 72 weeks even on the highest dose. - Patients appear to immediately gain the weight back as soon as they stop taking it. It's right in the phase 3 trial outcomes paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC10667099/ I suspe…

I've been on Zepbound for ~25 weeks now and one of the first things my doctor told me was that this was a lifetime drug. He pointed out that I had a choice, of lifetime drugs. I needed to do something to get my cholesterol under control. That meant start statins now and likely add blood pressure meds and diabetes meds in the next 2-5 years. Alternatively I could start Zepbound, which would likely address all 3 and re…

> Just look at the recent CVS Caremark forced switch from Zepbound (2nd Gen) to Wegovy (1st Gen) in July.

This is something I wasn't aware of, are you on 2nd gen Zepbound then?

My wife has been plateaued at an undesirable weight and has been wanting to try this, however, the VA refuses to support it regardless of the fact she fits their guidelines and requirements to receive it. They recently banned it due to costs.

I prefer her to use Zepbound if we can get it, the question is how? We refuse to use the alternative methods where the drug is hand made to be equivalent to them as that seems very sketchy.

Re: Ozempic shows anti-aging effects in trial

#675

Post by JackFr »

rscho wrote: post #664
radu_floricica wrote: post #390

Earlier quoted context omitted.

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over th…

> Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list.

Never knew about the potential stomach bleeds until I took my mother to the hospital earlier this year. Ironically, she was taking Motrin given to her in the same hospital a week earlier.

Re: Ozempic shows anti-aging effects in trial

#677

Post by shlant »

wpm wrote: post #640
p1dda wrote: post #290

Please stop with these obvious pharma ads, nobody needs to take Ozempic! Change your lifestyle and most importantly: STOP EATING JUNK FOOD

Oh fuck why didn’t we think of that!? You’re so smart!

it's good we have so many geniuses in these comments solving the obesity epidemic! if only they spoke up sooner :(

Re: Ozempic shows anti-aging effects in trial

#678

Post by rob74 »

selectodude wrote: post #669
rscho wrote: post #664

Earlier quoted context omitted.

Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over th…

I’ll assume OP meant low-dose aspirin having cardioprotective effects.

Aspirin isn't the controversial item on OP's list, antibiotics and ibuprofen are.

Re: Ozempic shows anti-aging effects in trial

#679

Post by peterldowns »

throwawaylaptop wrote: post #146
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

You can be gluttonous and still thin. I eat 2 lbs of ground beef a day, with tons of cheese on it. For breakfast I have 6-8 eggs, with cheese. I have my morning coffee with heavy whipping cream. For desert, I whip up some of the heaving whipping cream and have it with frozen berries thawed out. It drives gfs nuts but they're too anti fat to try it.

That's like 4000 calories. How much do you weigh / what's your exercise like?

Re: Ozempic shows anti-aging effects in trial

#680

Post by Damogran6 »

Roark66 wrote: post #593

This is all nice and all, but how can they tell these benefits are from ozempic or actual calorie restriction? Were talking about people that suffer from hiv induced bad fat distribution. I assume this means they have conditions such as fatty liver etc. Simple calorie restriction will improve their life. The study would have to do the exact same calorie restriction for both groups. One on ozempic, one without. Then i…

GLP-1, amongst other things, _enables_ the calorie restriction. It takes away the noise and tendency to overeat.
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