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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#661

Post by shlant »

a5c11 wrote: post #566
soulofmischief wrote: post #528

Earlier quoted context omitted.

Wow, I didn't realize the solution to all my problems is just to fix them. The answer was staring me right in the face the entire time. While I'm at it, I should also not take ADHD medication and instead just fix my mutated dopamine circuitry.

You don't quite understand the meaning of "symptom" and "illness", do you? Obesity - symptom. Usually the illness is a bad diet, lack of movement, or very rarely some serious health condition. Instead of targeting obesity, fix your habits or see a doctor to see why your body accumulates excessive amounts of fat. Dopamine issues, lack of concentration, etc. - symptoms. The illness is ADHD. By taking medicines you are…

wow people can just not be obese if they fix their habits! what a revelation! Better go tell all the obese people that, they surely have no idea.

Re: Ozempic shows anti-aging effects in trial

#662

Post by wonderwonder »

kjkjadksj wrote: post #26
pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

I agree, I'm 46. I dropped from 240lbs in January to 209lbs in June. I have maintained that weight. Recently went to a beach resort for a vacation and the number of random people that commented on my build was embarrassing. From bar tenders making a point of serving me first and asking me how much I benched to the literal wives of other men saying "Hi Vin Diesel" (3 times) in front of their husbands and my wife. I have a shaved head and tan so its going to always be Vin Diesel or the Rock. My wife even commented that people keep staring at me.

I literally realized how amazing life must be for a hot girl.

Must have been because of how disgusting I look...

I think you may be making things up to make yourself feel better friend.

Re: Ozempic shows anti-aging effects in trial

#663

Post by throwaway6041 »

anal_reactor wrote: post #570
Fargren wrote: post #493

Earlier quoted context omitted.

The way Japan "solves" obesity is quite cruel on those it does not work for. Overweight natives are not treated kindly. I think creating a medicine to make this easier is a moral good, and a sign of kindness and intelligence. Hopefully the aliens also agree.

What is more cruel: a) emotional damage b) heart disease

Alternative A can have the opposite effect. Unhappy people tend to eat more.

Perhaps it is a "motivator" for people to stop gaining weight by controlling their diet before they are too obese, but once you are obese I think it has mostly negative effects.

Losing significant weight is incredibly hard, and gets harder the more you want to lose. If you have lost 20kg (with great benefits to health) and are still made fun of because you are still above average weight it will have a negative effect and the weight will quickly be gained back

Re: Ozempic shows anti-aging effects in trial

#664

Post by rscho »

radu_floricica wrote: post #390
leoh wrote: post #209

Earlier quoted context omitted.

True enough, but many studies show that calorie restriction reduces effects of aging

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over the top.

Edit: I forgot. Ibuprofen also causes (non trivial) stomach bleeding and increases blood pressure. And many other things too.

Re: Ozempic shows anti-aging effects in trial

#666

Post by KPGv2 »

buu700 wrote: post #330
Aurornis wrote: post #228

Earlier quoted context omitted.

Eggs have about 60 calories each. Cooking 2lbs of ground beef could yield a little over 1500 calories (Source https://www.uhhospitals.org/health-information/health-and-we... ) A tablespoon of heavy whipping cream is 50 calories. There's nothing incompatible with what you wrote and a 2500 calorie diet. This confuses a lot of people who associate certain foods with becoming fat, or think that eating fat makes you fat.…

That’s a horrifying amount of saturated fat per day, though. This is an extreme risk for heart disease. I keep hearing this, yet after 13 years of keto my cholesterol is still 100. Being fat is much higher-risk than eating fat. I'm all for obese people taking Ozempic if they really need it, as well as thoroughly studying its long-term benefits and risks, but the fact that we're at the point of considering medical int…

> Take something like the food pyramid, and put vegetables on the bottom, put fat/dairy/coconut and protein/meat/eggs/soy/mycelium in the next level up, put fruit in the next level up, and put starches and sugars on top

You might be happy to know we replaced the food pyramid years over a decade ago. With MyPlate, a visual representation of what your plate ought to look like when it's healthy. Half fruits and vegetables (mostly veggies), a little over 25% grains, a little under 25% protein (protein and fruits are depicted as the same). Dairy is the smallest of all, as a small cup off to the side.

Totally disagree with your idea that starches (grains + potatoes, I assume was your thinking) as the smallest thing. You say "eat real food, mostly plants" and then exclude fruits and grains. You keep complicating your own rule without explaining the complication.

> demonizing saturated fat

are you a cattle rancher? There is oodles of research that saturated fat is bad for you. Full stop.

Here are some literature reviews:

- https://pubmed.ncbi.nlm.nih.gov/34649831/ (they actually have received funding from the beef industry and yet still agree that it looks like a diet high in SFA is linked to atherosclerotic heart disease)

On the other hand, you have bad faith actors like the ones who wrote this:

- https://pubmed.ncbi.nlm.nih.gov/36477384/ where they argue the anti-SFA crowd is a conspiracy-theory laden, unscientific group. If you read their (laughable) conflict of interest statement, they never once actually say anything about themselves, instead just bragging about how they're producing "revelations [that have] never before seen the light"

I actually am too lazy to pull up more. But keto people love to talk about how it's all a conspiracy. I'm glad it works for you. It obviously doesn't work for humans at large.

Re: Ozempic shows anti-aging effects in trial

#667

Post by shlant »

lm28469 wrote: post #602
ben_w wrote: post #545

Earlier quoted context omitted.

> If people can't be arsed doing that and we give easy shortcuts for everything in life, what's the point in being alive? Embrace the shortcuts. Life's too short not to. What's that Plato quote about writing? If men learn this, it will implant forgetfulness in their souls. They will cease to exercise memory because they rely on that which is written, calling things to remembrance no longer from within themselves, but…

The truth is that we designed a system in which a majority of people cannot thrive and in which a lot of people end up developing problems like obesity or being labeled as ADHD. Now the same system designed a cure, one that you have to pay for and take for years if not for life, just so that you can rewire your perfectly normal brain to fit in the very imperfect mold of what the system needs Taking antidepressant won…

know what makes it easier to fix/change your environment? when you aren't obese and everything in life is so much harder.

Guess what? you can both take ozempic AND fix the problems that caused the need to self-medicate with food (for example). In fact, I would be willing to bet that we see research coming out in the next couple years that shows people who lose weight with GLP-1's then go on to make better lifestyle choices because they confer many benefits that are much more obvious and attainable when you aren't obese and just fighting to get around in daily life.

It's a two-way issue - having some problems result in you being obese, but being obese also creates problems, makes them worse, and harder to address. Mental health issues for example can both cause obesity and be caused by obesity - if you aren't obese anymore then your mental health improves and you can then go onto address other issues you might not have been able to otherwise.

Lastly, you talk about "the system" as if that's not a two way relationship. People who have unhealthy habits they have trouble controlling create demand for services and products that are unhealthy - but if you have less people with unhealthy habits then that demand reduces and so do those unhealthy supplies.

Re: Ozempic shows anti-aging effects in trial

#668

Post by sjw987 »

ben_w wrote: post #578
sjw987 wrote: post #550

Earlier quoted context omitted.

There's a time and place for shortcuts. Health and fitness shortcuts hold more to lose than they do to gain. Sometimes the long way is better long term. A healthy attitude towards eating and fitness can, and usually does, elevate your life experience many times over. Taking a shortcut in these erases any personal development and learning experience you could get from finding a sport you love, changing your views on f…

> Health and fitness shortcuts hold more to lose than they do to gain. The entire history of medicine and sports science disagrees with you about that. It's all about knowing what the direct path to the goal is and not meandering around the metaphorical scenic route to those goals. > Taking a shortcut in these erases any personal development and learning experience you could get from finding a sport you love Or enabl…

I get the impression you're just conflating "shortcut" with "progress", based off of the original Plato example.

You clearly know what I was implying with many of the examples there and spun them into different directions. You don't want builders who take shortcuts building critical infrastructure to save time or hassle, nor do you want to be treated by a doctor who took shortcuts in their education and training.

If you want to become a professional athlete or sports person, tried and testing training methods, nutrition etc. aren't shortcuts. You still need to do those things consistently for years and years (much like staying in shape in general).

If somebody seriously wants to lose weight, they need to discipline themselves to eat better (and maybe supplement that with exercise). Just taking a shortcut weight loss jab without taking anything from it will just lead to the weight going back on (as in crash dieting), becoming an indefinite user of these drugs, or failing completely if the drugs ever become unavailable or develop long term side effects.

Re: Ozempic shows anti-aging effects in trial

#669

Post by selectodude »

rscho wrote: post #664
radu_floricica wrote: post #390

Earlier quoted context omitted.

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Ibuprofen increases the risk of cardiac event and is a common precipiting factor in renal failure. Most antibiotics also do not do only good things. The list is too long to write here. Side effects profiles change with research and marketing developments, but thinking these drugs are only beneficial is a bit over th…

I’ll assume OP meant low-dose aspirin having cardioprotective effects.

Re: Ozempic shows anti-aging effects in trial

#670

Post by throwaway6041 »

indymike wrote: post #584
b800h wrote: post #427

Earlier quoted context omitted.

The other side of this is related to morals. People learned self-discipline by having to moderate their diet. Replacing that challenge with an injection is another example of a world in which people are not challenged to grow as people, but merely go out and buy something to make themselves feel or look better.

> merely go out and buy something to make themselves feel or look better. I'm pretty sure there are benefits far beyond looking better.

Unfortunately, for those who are obese no amount of diet or exercise will give them the "perfect" body.

I see many who were overweight lose weight and get ripped, while others have no chance to reach that far. Someone with a BMI of 40 has basically ruined their body and while they may look better with a shirt, they will keep it on while on the beach because of the excessive skin.

The reward and motivation for a person with a few pounds extra and a truly obese person are simply too different. Someone who has not reached whatever weight threshold that fits their body type has a chance to look "normal", while the more obese person will reach a point where losing more weight has less impact even after plastic surgery.

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