651–660 of 868 posts
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Corticosteroids are also pretty damn dangerous
They all have uncomfortable side effects, especially the fatty-inducing ones. But insulin stands out for being able to kill you very quickly from a moderate overdose.
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"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…
I'm one of those watching on the side, wishing there would be a holistic, aggregated, view on all pros/cons that highlight each results statistical relevance as well (in particular it'd be great to understand test samples). On the natural evolution. I think it's best to think of it as a proces, with optimal state being a limit (e.g. in time, in total population), but especially in a changing environment. So, as it be…
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Wish I could run. Knee says no.
Do you have an injury? Knees over toes exercises can do wonders for rehab. From a form perspective, it also helps to avoid heel-striking.
Not heel striking. I wear thin shoes with no padding (barefoot style) so I couldn't even if I wanted to.
It could be some kind of form issue, I guess.
It's a mystery.
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> don't try to tell me I failed because of a lack of effort, understanding, exercise, "discipline", etc. Not to be _too_ rude here, but clearly you missed the mark on at least one of those things. If you're burning more energy than you're consuming, it's impossible to not lose weight. Maybe you underestimated how many calories you were consuming, overestimated how many calories you were burning, didn't do it often en…
The missing piece is that the body does not burn a constant amount of energy, and often the body's response to calorie restriction is to reduce the amount of energy used. [1] Play the weight-loss game with your body, and you'll find the goalposts get moved. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9036397/
Presumably the point at which it's VERY difficult to expend more calories than you're consuming is something of an equilibrium point, or healthy weight. I find it hard to believe that if you're still 100 pounds overweight after having lost say 20 pounds that it's nigh-impossible to find more "fat to trim" in the caloric intake, for example.
Basically everything that can be improved by exercising and maintaining a healthy diet.
Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.
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There is no doctor on Earth who goes to work and thinks "thank god for fat people or I wouldn't have a business". There's plenty of doctors and surgeons who wish there were less fat people, because they enormously complicate doing surgery on and managing in hospitals.
> There is no doctor on Earth who goes to work and thinks "thank god for fat people or I wouldn't have a business". What about everybody that works in liposuction?
They want to "fix you," too.
I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
I think there's a justifiable fear/dread when things that used to demonstrate virtues no longer do so. For instance, being in shape used to (usually) demonstrate discipline. Art or music used to demonstrate attention to craft and practice. Knowledge demonstrated time devoted to study. This isn't to say that the world is worse with these advances (I'd be hopeless without search engines, and I am grateful that people g…
Putting on weight may demonstrate a lack of discipline or awareness, but those losing weight should not be treated as only undisciplined. Scientific research shows that obesity changes the body in ways that actively work against you when you decide to lose weight. You may be able to loose the first pounds with "discipline", but it becomes increasingly harder the more you lose. Once you have lost a few pounds, the body actively works against you to get back to what it thinks should be the baseline.
Please stop with these obvious pharma ads, nobody needs to take Ozempic! Change your lifestyle and most importantly: STOP EATING JUNK FOOD
It really puzzles me how people would just pop a pill instead of make some lifestyle changes. Maybe it's just my personality type, but it disturbs me how most people just want something quick and easy instead of doing the actual work and becoming overall better via a real learning journey by struggling through changing bad habits. But whatever, they do whatever works for them! I don't like pharma.
Being fat really, really sucks, so most fat people have tried to make lifestyle changes, but they've gotten a lot of bad advice over the past half-century. They've cut back on fat, especially healthy animal fats, because that's what the government/medical/nutritional complex said to do, replacing them with "healthy grains," and only gotten fatter. They've tried to trim calories or portion sizes, which is difficult and ineffective for a lot of reasons. They've tried so-called weight-loss products promoted by corporations with millions to spend pushing them. They've thrown themselves into exercise plans, and while exercise is great for a lot of reasons, it doesn't have much effect on weight loss.
Even when they go outside the mainstream and try something that can actually work, like cutting carbs or fasting, it's difficult because losing weight isn't just the reverse of gaining weight. Fat cells aren't just buckets that fat falls into and can fall out of. Once energy is stored in the form of fat, it has to be burned to be removed, which requires a different set of hormones and enzymes than storing it did. Maintaining that metabolic mix generally requires an enormous amount of willpower, not just some lifestyle tweaks. People who have plenty of willpower to succeed in other areas of life like career or relationships can be defeated by it.
I don't like big pharma either, and I'm losing weight (slowly) with fasting rather than trying these drugs. But it's hard to blame people for using them, if it's a temporary fix and they're going to maintain their new weight through diet. I'm skeptical that it'll go that way for many, but I suppose there's hope.