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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#641

Post by wonderwonder »

skeezyboy wrote: post #510
otikik wrote: post #454

Earlier quoted context omitted.

There is another way to look at it. People who don't experience difficulties moderating their diet and could flounder their "self discipline" are now on a level field with people who did have difficulties with their diet. So they feel threatened by it. Another example of a world in which people are not challenged to grow as people; instead of being happy that more people can get healthy they dismiss the medical advan…

go out and get some exercise, run around, why is this never an option?

I've worked out my entire life. Always one of the strongest people in the gym. Almost always overweight. Not obese but overweight. Once I had kids I really packed on the pounds. In January I got on GLP1s and over 4 months dropped from 6'1 at 240lbs to 209lbs. I'm 46 years old with defined abs and a bench of over 405lbs. My BP has gone down and I am in a healthy range for the first time in 20+ years. My cholesterol is perfect now. I feel 20 years younger. I stopped snoring for the first time in 2 decades. My wife sleeps like a baby now which is probably the most important change. I wake up and jump out of bed fully energized and rested for the first time in decades.

Sometimes people just need a helping hand. There is no shame in that.

It appears your issue is that you just don't think its fair and that people should have to take the long way. I would argue that's a you issue and not an us one.

Re: Ozempic shows anti-aging effects in trial

#642

Post by xienze »

guerrilla wrote: post #574
xienze wrote: post #538

Earlier quoted context omitted.

> don't try to tell me I failed because of a lack of effort, understanding, exercise, "discipline", etc. Not to be _too_ rude here, but clearly you missed the mark on at least one of those things. If you're burning more energy than you're consuming, it's impossible to not lose weight. Maybe you underestimated how many calories you were consuming, overestimated how many calories you were burning, didn't do it often en…

I count my calories accurately. The problem is keeping consumption that low in the long term. It's not sustainable. Your body does everything to fight you and it only gets harder the further you go.

Well that's where the "discipline" part comes in.

Re: Ozempic shows anti-aging effects in trial

#643

Post by throawaywpg »

skeezyboy wrote: post #531
komali2 wrote: post #514

Earlier quoted context omitted.

Because it isn't, so oh well. I'm continually frustrated with the four thousand year old history of people being surprised that other people "don't just ${something good for you} and don't just stop ${something bad for you}." Great, we've tried the "Acting surprised people do unhealthy or bad things" strategy and the "scolding people for doing unhealthy things" strategy for a couple millennia and people still do the…

youre distant ancestors chased every meal they ate. your more recent centuries old ancestors probably worked 6.5 day weeks, 12 hour shifts, and had to have all the children working as well, for a pittance. YOU on the other hand have no problem finding any kind of out-of-season food and probably drive everywhere, barely lifting a finger in comparison. THIS IS THE DIFFERENCE. Why were there no obese (poor) people 100 y…

they didn't have ultra processed foods 100 years ago!

Re: Ozempic shows anti-aging effects in trial

#644

Post by gavinray »

glp1guide wrote: post #506
gavinray wrote: post #491

Earlier quoted context omitted.

I've used Retatrutide and wasn't that impressed I used 5mg/wk (Have used Semaglutide, Tirzepatide, and Retatrutide. For Sema/Tirz, I've had both RX and grey market.)

Interesting -- would love to hear anything more you have to share! The research numbers would suggest that Reta was top, results wise. Any other significant differences you felt/noticed? Also, do you find Tirz to be an imiprovement over Sema?

Yes, so far my preference has been Tirz. Though cost for Sema is significantly less.

It could also be the case that the dose on the Reta I used was too low. I've had a few people mention that they also felt it was fairly weak mg-for-mg, maybe 10mg would have been better.

There is a newer formulation, combining Sema with Cagrilintide that is probably the most effective option atm:

https://www.nejm.org/doi/full/10.1056/NEJMoa2502081

Price wise, this should give a general idea what Chinese sources sell at:

  Semaglutide 10mg/vial x 10vials $80
  Tirzepatide 10mg/vial x 10vials $72
  Retatrutide 10mg/vial x 10vials $130
  Cagrilintide 5mg + Semaglutide 5mg 10mg/vial x 10vials $170
(Note that even though Tirz is a few dollars cheaper, 2.5mg Sema = 15mg Tirz or thereabouts)

Re: Ozempic shows anti-aging effects in trial

#645

Post by shlant »

dawnerd wrote: post #165
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

The same thing with keto. People will swear it's unhealthy but like, the alternative (outside of Ozempic and co) is being overweight...

in no world is keto the only option for most people. Some may personally feel it's easier than other dietary/lifestyle options for losing weight but it is not uniquely different than many other options in that category (and absolutely has risks depending on how it's done)

Re: Ozempic shows anti-aging effects in trial

#646

Post by briangriffinfan »

dan-robertson wrote: post #505
ap99 wrote: post #503

This, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (…

Is it possible to avoid having the same discussion every time anything related to Ozempic comes up?

My manfriend is on ozempic and he always complains about how it makes him alternate between constipation and diahrrea. So it was funny to me to see it become a meme.

Re: Ozempic shows anti-aging effects in trial

#647

Post by shlant »

glp1guide wrote: post #269
jjice wrote: post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0]. https://glp1.guide/content/novo-nordisk-patent-protections-l...

> and the side effects can be severe

Are there severe side effects that aren't extremely rare? can you provide data on this?

Re: Ozempic shows anti-aging effects in trial

#648

Post by KPGv2 »

kulahan wrote: post #186
pessimizer wrote: post #158

Earlier quoted context omitted.

The irony is that all that "it's so easy" "it's just calories in, calories out" "if you eat according to this plan and make sure to get 8 hours of sleep a day, you won't even feel the cravings" Is stuff that fat people say. They totally buy into it and buy all of the products to help them convince themselves this is true. Then they get disillusioned when it doesn't work, have a crisis of faith, then go to the next fa…

I’m certain IF more closely resembles how humans ate for millions of years, not knowing when our next meal would come before becoming an agrarian society, and we haven’t had much time to evolve since then. So, yeah, dieting is modern, but so is an abundance of food. Both are equally unnatural.

This is literally the argument keto, carnivore, and caveman diet people make. "I feel like this is how we ate 10,000 years ago, so it must be natural and therefore good!"

We also didn't get vaccines for most of history. That doesn't mean remaining unvaccinated is good.

For the record, keto works for me (including bloodwork to prove it) but is unsustainable. My mind is never sufficient compared to when I'm eating normally. It's observable in my work and parenting. Although, last time I was on keto, my cholesterol was through the roof. I went off keto and three months later numbers were back to normal. And I wasn't consuming a shitton of meat and butter or anything. I was pretty close to exactly the right numbers for optimal health. Just...something made the numbers terrible and I've no idea why. Did a re-test to confirm. Same awful cholesterol.

On IF I actually got fatter. Numbers worse. Less healthy. Couldn't exercise as vigorously.

For me, calorie counting works. It's also not sustainable, because with kids you get in a rush and if you have a normal social life you eat at places you can't calorie count.

To stay healthy I just try as hard as I can and exercise (distance running, weightlifting, tennis when I can, which is pretty rare with three young children).

Re: Ozempic shows anti-aging effects in trial

#649

Post by Dah00n »

getpost wrote: post #144

In a recent podcast[0], Ben Bikman explained some of background and pitfalls of GLP-1 drugs. When the drugs were first prescribed, dosages were much smaller than the dosages now prescribed for weight loss. Microdosing might be a better and safer strategy. The podcast is only 3 hours long! The GLP-1 discussion starts at 2:09:53. [0] https://www.foundmyfitness.com/episodes/ben-bikman EDIT: ycopilotFYT version https://w…

Only 3 hours!

Re: Ozempic shows anti-aging effects in trial

#650

Post by ranger_danger »

nradov wrote: post #255
42772827 wrote: post #241

Earlier quoted context omitted.

The choice is no longer between "cutting out bread and sugar completely" and "some kind of lifelong moderation for a person that has struggled." The choice is now between "cutting out bread and sugar completely" and "removing the struggle to moderate bread and sugar." You're clearly an advocate for your father making healthy choices. So why would you advocate against the use of a drug that makes that easier?

Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.

If it's so easy why does the drug even exist? Why is it so popular? Why isn't everyone just changing their habits so easily like you say?
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