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Ozempic shows anti-aging effects in trial

trial.medpath.com

621–630 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#621
post #588

Earlier quoted context omitted.

> our bodies don't just produce more GLP-1 Dominant subgroups in a species are dominant because their parents survived that last set of pressures (external death inducements) at a higher rate than other subgroups -- but won't necessarily see the same results with the current set. Even 90 years ago, there was significant loss of life due to famine, so selection was towards people who could efficiently gain and store c…

> but good quality food is expensive (in the US -- many other parts of the world have their quality food cheaper but I digress Let's digress. I read this frequently in various forms on this forum, and it's always "just so" justification. My own heuristic thought is that "low quality" food (high energy, long shelf-life processed foods) is very cheap because it is produced at scale and can be stored, while "high qualit…

> Expensive food is expensive, but I would bet quality food is cheaper here than anywhere else.

Having lived in a few other countries with less industrialized distribution networks, no, this claim is dramatically incorrect. Fruits, vegetables, staples like rice, and basic forms of protein (fish, insects and sea critters, some chicken) are much, much cheaper relative to processed foods. Larger protein sources like beef, pork, or bushmeat is relatively more expensive, however, unless you opt for poor quality processing like cheap "corned beef" made from offal.

As an economist, I appreciate the difficulty of making apples-to-apples comparisons across countries for things like food prices, as even the acclaimed "Big Mac Index" assumes that a Big Mac has a similar relative status across countries (though the oft-misunderstood intent of the Big Mac Index is to more to compare consistent production costs). In some places a Big Mac is fancy, in the US it is considered fairly garbage but consistent.

For example, in a market in the Philippines, you have mostly cash transactions and informal capture for what the majority of people purchase. The purchasing is done more in these almost farmers-market style transfer versus grocery stores in the US. They _do_ have grocery stories, but almost uniformly for processed food distribution versus fresh food in the markets. It's much cheaper to eat healthier from the markets and through the informal distribution network of sari-sari stores versus equivalent nutrition from processed food from the grocery stores.

Also, consider the results of this recent study: https://arstechnica.com/health/2025/08/in-trial-people-lost-...

Re: Ozempic shows anti-aging effects in trial

#622
post #358

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great then how come our bodies don't just produce more GLP-1?

Idk, why can’t we synthesise vitamin C? Why do we have a bent oesophagus prone to choking and heads bigger than womena’ hips?

We weren’t intelligently designed. To the degree we were optimised for anything it isn’t the modern environment. A lot of pushback against medicine in general seems to derive from an underlying belief in an innate perfection of human biology.

Re: Ozempic shows anti-aging effects in trial

#623

Earlier quoted context omitted.

[flagged]

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything. At most a drug rep comes by and brings donuts or something to talk about their new drugs. Source w…

https://projects.propublica.org/docdollars/

https://openpaymentsdata.cms.gov/

Re: Ozempic shows anti-aging effects in trial

#624

Earlier quoted context omitted.

I am one of those people to some extent. For me, it's the naturalistic fallacy I can't get over. I drink caffeine daily, but the idea of hijacking my hunger with an injectable induces dread. I would like to believe that there are no long-term side effects, but: 1. We have to trust the data of for-profit pharmaceutical companies and their trials. They are incentivized to produce optimistic results. 2. It's relatively…

I'd trust for-profit pharmaceutical companies before I would trust "all chemicals are evil and bad" Facebook moms.

Clearly you missed the part about name-calling. Anyways, that's a false dichotomy since you can be a third option: someone that's skeptical of messing with an important energy consumption pathway in the human body.

Re: Ozempic shows anti-aging effects in trial

#625

Earlier quoted context omitted.

I am one of those people to some extent. For me, it's the naturalistic fallacy I can't get over. I drink caffeine daily, but the idea of hijacking my hunger with an injectable induces dread. I would like to believe that there are no long-term side effects, but: 1. We have to trust the data of for-profit pharmaceutical companies and their trials. They are incentivized to produce optimistic results. 2. It's relatively…

>It is/was made of a poison from an animal. Caffeine is an insecticide.

Right, and it's also not something naturally in the human body. But sugar is also an insecticide when you cook it into a jam. It doesn't really make me comfortable with giant lizard poison

Re: Ozempic shows anti-aging effects in trial

#626

Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.

It works because people feel 'full' sooner. They do still try to overeat, but feel they can't (and yes, there is habituation as they try day in day out). I'm pretty sure the food industry has been working on a neutralizing agent to add to their preparations since day 1, so the 'victory' wont last.

As for longer term consequences? Who knows?

Re: Ozempic shows anti-aging effects in trial

#628

Earlier quoted context omitted.

> If Ozempic is so great then how come our bodies don't just produce more GLP-1? To store calories so you don't starve. This is a failure mode of evolution and there is in fact "free lunch" when we use technology to reoptimise our bodies to calorie abundance

> when we use technology to reoptimise our bodies to calorie abundance replace "calorie abundance" with "sedentary lifestyle" and youre there. its people eating more than they burn off because they dont exert themselves because thats what being an adult means.

> replace "calorie abundance" with "sedentary lifestyle" and youre there

Our lifespans have increased with our sedentary lifestyles.

Exercise is part of it. But we’re clearly working to transcend our natural health spans in a comfortable, modern environment. That will require the application of intelligence to the problem, not just brute force.

Re: Ozempic shows anti-aging effects in trial

#629

Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.

[dead]

Re: Ozempic shows anti-aging effects in trial

#630

Earlier quoted context omitted.

This concept would be hard to grasp for me if I did not know personally a person facing such issue. I don't think most people can understand that "just eat more" does not work in such cases, because most people can eat just fine even if not really hungry.

> because most people can eat just fine even if not really hungry. I literally cannot imagine how this is possible. Don't you feel full? Doesn't your body start refusing to swallow? Doesn't the food turn tasteless and start making you nauseous? 100-200kcal over your BMR, sure, but beyond that?

No, those are symptoms of an eating disorder.
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