621–630 of 640 posts
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I've been on GLP-1 for a month and my triglycerides halved, and my cholesterol dropped to the levels it was in my twenties. If that's not a predictor of lower mortality, there's something wrong with our fundamental medical knowledge.
I agree! (is this responding to part of my comment? :) )
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Having ADHD myself, and a bunch of friends who also have it, I have noticed that the people with this condition rarely have a healthy relationship with food. There is either a tendency to overeat indulgent foods, or a tendency to not think about food that much. I have also heard about people with ADHD being on GLP1 agonists that it does a lot for their reward seeking behavior and impulse control. This makes me wonder…
As I wrote to another person here: Yes. Not as much as with ADHD medication, but there is an obvious subset of addictive personalities that find relief from addictive behaviors (beyond eating addiction) with semaglutide. But to add to this, I feel like there are different kinds of addictive behaviors at play that are more susceptible to one medication or the other and are based on different systems. For instance, the…
Emotional regulation issues are one of the most difficult ADHD traits and it's quite under recognized for how badly it affects many of us. This is likely the reason why anxiety misdiagnoses are also fairly common.
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Scroll down to the area referencing footnote 9 in this article https://pmc.ncbi.nlm.nih.gov/articles/PMC11457043/ That articulates it better than I will
Like I said above, they don't extend exclusivity or prevent practice of expired IP. All you have to do is not infringe the new IP. this is what the article says too. I disagree with their greater claim; The patents aren't rocket science- most are extremely easy to read, and the authors are hiding behind weasel worlds like "may" and "could" There are some bad patents that should never have been granted, like Novartis'…
It’s rarely because of a new technological breakthrough, but rather a way of drug companies lengthening the time they can profit off a drug.
If they released it earlier they would simply take market share from themselves, but by releasing it close to the time of generics they take market share from generics.
Why didn’t Wegovy come out 5 years sooner? Why does it use a different injector than Ozempic? I don’t know but sounds quite similar to the ER/XR strategy.
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Why not? We have an overweight and obesity epidemic that has persisted through everything else we've gotten enough political capital to try thus far. The "miracle" drug is the most promising direction we've had in a long time. Whatever possible adverse long term effects have to be (plausibility they actually happen) x (harm they cause) > known harms of being overweight. The scale of the solution is allowed to match t…
"We've tried nothing and we're all out of ideas" The obesity trend has happened almost in lockstep with the proliferation of highly processed foods. Butter and animal fats being replaced with low quality, hydrogenated vegetable oils. Cane sugar being replaced with high fructose corn syrup and other highly processed sweeteners. Sodas and sugary juices replacing water. Food like substances with little to no nutritional…
Matt Levine in his column actually addressed that GLP1 could cause the junk food/alcohol/other addictive stuff industries to lose a lot of money due to less consumption.
It's possible that junk food becomes a niche thing given enough time and GLP1.
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"We've tried nothing and we're all out of ideas" The obesity trend has happened almost in lockstep with the proliferation of highly processed foods. Butter and animal fats being replaced with low quality, hydrogenated vegetable oils. Cane sugar being replaced with high fructose corn syrup and other highly processed sweeteners. Sodas and sugary juices replacing water. Food like substances with little to no nutritional…
I agree with every word of your analysis and I agree that we've tried basically nothing. But this is why I talked about political capital—every one of your suggestions has been available for the last twenty years and nothing has come of it and the problem continues to get worse. When you say something like, "healthy food should be more affordable and readily available" you'll get a lot of nods of agreement but when i…
The thing with healthy food is not that they are expensive, because they aren't, raw veggies, whole grains, raw chicken, raw pork are not that expensive, especially if you buy in bulk. The problem is that it takes time to cook them, which people may not have, and in general (at least the USA), I feel like people suck at cooking, and don't really have a good food culture of enjoying cooking, like italians do for example.
I believe something similar happened to cigarettes, they are super taxed as well as all the health campaigning around them.
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It's a social contract between the people and the enlightened. The people always win on a long enough timeline. But the deal is there should be some sliver of reward for a brief window of time to those who bring permanent light into our lives.
The "enlightened" are the scientists who actually developed this stuff, not the CEOs and corporate shareholders collecting economic rent from other people's hard work who pocket the vast majority of the profits. If we only had to fairly pay the people who actually did the useful work and not all the capitalist deadweight, these drugs would be orders of magnitude cheaper.
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For mortality tables age and sex are pretty much sufficient to get to 98% accuracy.
You definitely (at least in the US) need income (or an income proxy like zip code). Mississippi has a life expectancy ~10 years less than Massachusettes.
Men under 40 essentially have incredibly low mortality. Once you exclude cars and suicide it drops basically to zero.
Even things that are very very bad for you, like being very obese (BMI>40), are factors that scale a mortality that is massively dominated by age and sex. Even 3x mortality at 25 rounds to zero. At 60 background become 1% per year and a 3x increase would make a huge difference.
I would wager $50 that there are no contiguous collection of zip codes in the USA where the average 40 year old has a higher life expectancy than the average 30 year old in any other contiguous set of zip codes assuming there are over 1000 people of that age in both.
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The "enlightened" are the scientists who actually developed this stuff, not the CEOs and corporate shareholders collecting economic rent from other people's hard work who pocket the vast majority of the profits. If we only had to fairly pay the people who actually did the useful work and not all the capitalist deadweight, these drugs would be orders of magnitude cheaper.
And you think scientists should be working for the communists instead of the capitalists? Well that's fine too. Scientists are like spoils of war. Scientists were treated well and able to do a lot of good work when they were all employed by the soviet state. Maybe not as good as the Americans did. They also seem to be doing well over in China. But just because you don't like someone or how they do business, that does…
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can you explain this statement to me more? I think i'm missing something
The health insurance companies are paid as a percentage of the amount of care that flows through them. So healthier customers means their profit is 5% of SMALLER_NUMBER.
I don't think this is completely true right? Rather, it's more accurate to say that customers that are seen as healthier get to pay less premiums, but customers that are seen as unhealthy have to pay more.
In both scenarios, you, as the insurance company, still want to be minimizing the amount of care you actually pay for.
In other words, to maximize profits, it seems like the best customer is one that's high risk (high premiums), but less likely to require a catastrophic payout. In which case, it feels like an obese high risk patient on ozempic seems like a pretty solid deal.
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And you think scientists should be working for the communists instead of the capitalists? Well that's fine too. Scientists are like spoils of war. Scientists were treated well and able to do a lot of good work when they were all employed by the soviet state. Maybe not as good as the Americans did. They also seem to be doing well over in China. But just because you don't like someone or how they do business, that does…
Let's not assume self‑interested corporate monopoly rents are a necessary precondition for innovation, and let's drop the romanticized notion that statutory patent terms by themselves constitute a just moral bargain, because history shows substantial discovery emerging from publicly funded science, mission driven nonprofits, collaborative consortia, open licensing, prizes, and advance market commitments, so we should…