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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#611
post #588
post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> our bodies don't just produce more GLP-1 Dominant subgroups in a species are dominant because their parents survived that last set of pressures (external death inducements) at a higher rate than other subgroups -- but won't necessarily see the same results with the current set. Even 90 years ago, there was significant loss of life due to famine, so selection was towards people who could efficiently gain and store c…

> but good quality food is expensive (in the US -- many other parts of the world have their quality food cheaper but I digress

Let's digress.

I read this frequently in various forms on this forum, and it's always "just so" justification. My own heuristic thought is that "low quality" food (high energy, long shelf-life processed foods) is very cheap because it is produced at scale and can be stored, while "high quality" (fresh products) is not cheap for the opposite reason.

The US has the cheapest food in the world [1]. Expensive food is expensive, but I would bet quality food is cheaper here than anywhere else. The "problem" is that when presented with a cheap, easy, tasty, high calorie food option against a relatively more expensive "quality" option, consumers choose the former because it's cheaper, easier, tastier, and provides more calories. I would bet this is even true when the absolute difference in price is small.

[1] https://www.fastcompany.com/91208387/food-grocery-prices-us-...

Re: Ozempic shows anti-aging effects in trial

#612
post #358

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

Natural selection optimizes for long term survival of genes. Humans are probably long-lived because we have high maintenance offspring and a survival strategy built around communicating culture, but this only necessitates survival through 2-3 generations worth of time. Anything beyond that won't be selected for.

Same with health, etc. A bio professor once said "life doesn't work perfectly, it just works." There's a lot left on the table because evolution optimizes for the median case over time.

Re: Ozempic shows anti-aging effects in trial

#613
post #360

Earlier quoted context omitted.

And odds are very firmly that you'll fail. That's what the science shows us.

having the understanding of the science and self motivated enough to make lifestyle changes already puts you a couple standard deviations out of the population average, such that I don't really think its helpful as a comparison or something to model after

The science is clear that people who do make changes and achieve initial results are still overwhelmingly likely to fail at maintaining the results.

Lots of people successfully make changes and lose weight, but exceedingly few manage to keep it low over time.

Re: Ozempic shows anti-aging effects in trial

#614
Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil…

Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss.

Ozempic is currently the NVIDIA of the pharmaceutical industry.

Re: Ozempic shows anti-aging effects in trial

#615
post #579

Earlier quoted context omitted.

Visit Turkey for a couple weeks. Rules are the same, but behavior is the opposite. Weekly dose of 1mg is sold over the counter for around 150$.

And it's thanks to that kind of dishonorable practice that $NVO has lost 64% of its value over the last year. This is how the world rewards the makers of the most successful and helpful drug in history.

They’ve been rewarded enough (~$14.65B USD net profit 2024), and are lucky they’re allowed to capture any further economic benefit from the sale of a simple compound (imho).

Re: Ozempic shows anti-aging effects in trial

#616
It sounds like the researchers failed to compare their semaglutide group to a calorie-controlled placebo group. The beneficial changes noted in the semaglutide group could very well be due to reduced calorie diet, rather than a specific effect of the drug itself.

This is why people end up skeptical of academic types and science publications.

Re: Ozempic shows anti-aging effects in trial

#617

Earlier quoted context omitted.

[flagged]

Run a study of your approach and show good results over a cohort for 2+ years and you'll make an entire sub-field of medical scientists very happy. [EDIT] It's not that your approach can't work, it's that if (for example) people had as hard a time following the directions for condoms as they do following diet & workout plans, we'd never allow condoms to be sold as contraceptives, they'd not even be close to being OK…

87% of people in this study reversed t2d or prediabetes with diet and exercise: https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291...

Re: Ozempic shows anti-aging effects in trial

#618

Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.

> Only slightly better than 1800s snake oil

In the same vein folks were disputing the validity of vitamin C until WWII [1].

There is no shortcut to science. You have to weigh the evidence. Currently, the evidence in favour of GLP-1 agonists is overwhelmingly positive.

[1] https://pubmed.ncbi.nlm.nih.gov/23183299/

Re: Ozempic shows anti-aging effects in trial

#619

Just wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.

> Just wish there weren’t so many false “studies” promoting benefits of medications that have none

What’s an example of such a study?

Re: Ozempic shows anti-aging effects in trial

#620
post #358

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

If insulin is so great why does my pancreas simply not produce it?
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