Live data from Hacker News

Dementia 'linked' to common over-the-counter drugs

bbc.co.uk

61–62 of 62 posts

Re: Dementia 'linked' to common over-the-counter drugs

#61
post #51

This is apparently a new study, but the idea is not new. For example, see this article from American Family Physician in 2009: http://www.aafp.org/afp/2009/0301/ot2.html A quote: > Background: Medications with anticholinergic properties are often associated with adverse events, including falls, cognitive dysfunction, delirium, and loss of independence. That's from 2009, and it is stated as something already known. Al…

That's weird... The following article has a quote from one of the dementia study authors that specifically calls out loratadine/Claratin as an antihistamine that does not have anticholinergic effects: http://www.telegraph.co.uk/news/science/science-news/1137023...

This article examines and compares the anticholinergic effects of antihistamine drugs. It seems that loratadine has an anticholinergic potency greater than chlorpheniramine which is one of the experimented drugs in the study.

http://www.ncbi.nlm.nih.gov/pubmed/15627436

Re: Dementia 'linked' to common over-the-counter drugs

#62
post #16

I wonder if choline supplementation would counteract this effect. In fact, I wonder if choline supplementation might help stave off dementia in general. As much as 90% of the population may be deficient in choline.[0] [0] http://en.wikipedia.org/wiki/Choline#Groups_at_risk_for_chol...

Sadly, choline promotes the production of TMAO by gut bacteria, which in turn promotes the formation of arterial plaque.
Post reply on HN