Earlier quoted context omitted.
Yet another data point here... After using the ergonomically suicidal Apple Magic Mouse and Apple wireless keyboard, I developed RSI after just a couple of months. I having my wrists and forearms massaged every night until the tightness went away (for the night), and I switched to a mechanical keyboard, a nice-sized gaming mouse, and started mousing with my left hand at work. I haven't had any RSI symptoms for over 2…
Instead of a gaming mouse I had great success with trackballs. I have no idea why they fell out of favour - I remember them being rather popular some 10-15 years ago. Anyway, with a trackball I don't need to move my hand at all, except when switching from keyboard to mouse and back. I use this one: http://www.logitech.com/en-ca/product/trackman-marble YMMV, but I don't think I'm ever going to return to using mouse.
Trackballs are much faster. Given that I might switch from keyboard to trackball thousands of times per day, saving just one second by knowing where the trackball is, saves quite a bit of time. I also find it faster and more accurate for selection work to use my thumb instead of the much larger muscles used for mice.
I don't do much gui work other than clicking links in a web browser but when I do I find the trackball to be superior.