Documentary: The Cholesterol Code
FDA approves new kind of cholesterol pill
61–70 of 74 posts
Re: FDA approves new kind of cholesterol pill
#62What is the current state of understanding on high cholesterol as a leading or trailing indicator of poor health? I vaguely remember reading one theory that cholesterol was used by the body to mitigate arterial damage from other causes?
It (Particularly ApoB/Combining LDL-C and Lp(a) is one of the single largest leading indicators of health risk we have. If anything, the data we have is suggesting we've gotten wrong what the upper limits should be for what is considered OK. https://www.lipidjournal.com/article/S1933-2874(25)00317-4/f...
Isn't diabete and metabolic syndrome way more predictive than ldl or apob?
Do you have a reference comparing the various factors?
Re: FDA approves new kind of cholesterol pill
#63Earlier quoted context omitted.
Peter Attia had a great series of blog posts on this before his fall from grace: https://peterattiamd.com/the-straight-dope-on-cholesterol-pa... He also had a series of podcast interviews about this with Tom Dayspring. I believe his explanations are all mainstream, except he favors treating LDL and LP(a) more aggressively than normal doctors
Wait, why did he fall from grace?
Epstein files showed he neglected to visit his seriously sick son because he was hanging out with Epstein. He still knows his stuff, asshole or not.
Re: FDA approves new kind of cholesterol pill
#64What is the current state of understanding on high cholesterol as a leading or trailing indicator of poor health? I vaguely remember reading one theory that cholesterol was used by the body to mitigate arterial damage from other causes?
Peter Attia had a great series of blog posts on this before his fall from grace: https://peterattiamd.com/the-straight-dope-on-cholesterol-pa... He also had a series of podcast interviews about this with Tom Dayspring. I believe his explanations are all mainstream, except he favors treating LDL and LP(a) more aggressively than normal doctors
Wow the guy did Mechanical Engineering and Applied Math before going into medicine and surgery.
Re: FDA approves new kind of cholesterol pill
#65One could eat healthy instead of course but hey, the good life .
Lose weight, yes.
Exercise, yes.
Accept a potentially fatal genetic defect when an option is available? No.
Advise not callously generalizing your opinion on things like this. It's clear that you either spoke without knowing more, which happens, or you really don't seem to care to know more. I hope you're not in the latter.
Re: FDA approves new kind of cholesterol pill
#66What is the current state of understanding on high cholesterol as a leading or trailing indicator of poor health? I vaguely remember reading one theory that cholesterol was used by the body to mitigate arterial damage from other causes?
There isn't a conflict between cholesterol having a useful role in the body and too much being harmful.
There are mountains of evidence establishing a causal relationship between elevated cholesterol levels and heart disease.
Re: FDA approves new kind of cholesterol pill
#67Earlier quoted context omitted.
For all people? No. For the vast majority of people? Yes. Eat healthy and exercise more.
The dietary impact on cholesterol in the blood is surprisingly low. Looking it up, this source says diet can affect 20-30% of your blood levels [1]. I don’t have a great statistic about exercise, but I’d encourage you to question what you think you know — at the very least I’ll claim you’re mistaken about the importance of dietary impacts on cholesterol, which perhaps should give you pause about your other beliefs [1…
Fiber intake has a dose-dependent effect on cholesterol levels.
Obviously some people still need medication if they have particularly unfortunate genetics.
Re: FDA approves new kind of cholesterol pill
#68Earlier quoted context omitted.
eat healthy as in: only once a day and only six days a week. only water for drinking and only fresh stuff to eat, no meat, no eggs, nothing cooked, nothing baked, nothing fried, nothing grilled, nothing processed, no sugar and no salt. Being a major shift from the good life one should start it with a 7 day water fast. (do I have to say "ask your doctor before embarking"? done)
Yeah, when you grow up, get back to this comment to look how childish it is.
Re: FDA approves new kind of cholesterol pill
#69One could eat healthy instead of course but hey, the good life .
Eating healthy is a sub-optimal solution. Typically we see the most significant results with lifestyle changes + medical interventions and pharmaceuticals - more than either alone.
There's a strange belief, I believe most born out of morality, that medicine undermines discipline or healthy lifestyle. But it does not, they work in tandem, each making the other stronger.
It is true that taking medication is "easy" - not that easy, though. But easy != evil or immortal. If it's so easy, that's a good thing. It means we can stack it on top of lifestyle changes for very little marginal cost. If you're already working out and eating good, that's great. Go to your cardiologist and see if you're a candidate for statins or hypertension medication.
Re: FDA approves new kind of cholesterol pill
#70Earlier quoted context omitted.
you didn't read the article did you? Or are you actually here to claim that people with hypercholesterolemia just need to eat better? Do you have the same simplistic ideas about GLP-1's?
For all people? No. For the vast majority of people? Yes. Eat healthy and exercise more.
wow you figured it out! but wait.. if it's that easy why is obesity such a huge issue?