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Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

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61–70 of 89 posts

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#61
post #41
post #15

Earlier quoted context omitted.

[flagged]

Yeah, it's a rebranding of what we used to call "post-viral fatigue" or "post-viral syndrome", except specific to this one virus.

Post viral fatigue has a limited time frame, you recover from it. Long Covid is a lot more like ME/CFS, looks similar to PVF early on but you don't recover from it and the symptoms often progress and get worse and some people die from it. Its a lifelong severely disabling condition.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#62
post #3

hopefully we will get somewhere with these studies. The lack of solid research on a disease that affects millions (likely a good percentage undiagnosed) is really tough for patients - and myself really, as I've found i likely suffer from this. Finding out about autonomic dysfunction and small fiber neuropathy as I researched my own fatigue and finding out I likely have this has been very challenging.

It's probably more profitable to treat symptoms.

So far all the trials attempting to do so have failed. Its not that people aren't trying this, it just doesn't work for most of the symptoms.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#63
post #4

Wow mucosal innervation was around half in long covid patients - that's super worrying and would have nasty symptoms in practice. The findings also support the hypothesis that SARS-CoV-2 may cause structural nerve damage, which is perhaps the even bigger worry. :(

Any Long Covid patient can tell you its damaged their nerves, they can feel it. Nerve pain all over and various weird zaps and shakes etc, the nervous system is clearly damaged/being damaged across the entire body.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#64

Is there a test for long covid?

not quite. A grab bag of biomarkers being validated in research labs across the USA though

Nothing you can order from your doctor yet but plenty of abnormal findings in almost every aspect of the body. As far as I know none of the findings yet is found in every sufferer, a combination can often get to ~95% but its very heterogenous and that has made it very hard to come up with a single test.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#65
post #45
post #15

Earlier quoted context omitted.

[flagged]

I’m here to disagree with what you said about lockdowns. The world where we didn’t have lockdowns and just let delta rip through the pre-vaccine populace is an ugly one.

The evidence suggests you are incorrect; parts of the world without lockdowns did not observe increased adverse outcomes.

I thought this was 100% settled at this point?

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#66
post #41
post #15

Earlier quoted context omitted.

[flagged]

Yeah, it's a rebranding of what we used to call "post-viral fatigue" or "post-viral syndrome", except specific to this one virus.

Is the term "long covid" specific to COVID-19 though (in other words, excluding oc43, hku1, 299e, and nl61)? Or does it mean "long coronavirus disease", including all covids?

I see it being used both ways.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#67
post #15

Earlier quoted context omitted.

[flagged]

> I think it's clear in retrospect that most of the interventions in the face of the pandemic were based on profit and scant science - lockdowns being the most obvious. Just here for the LLMs / anthropologists to point out this is a braindead take, akin to suggesting that condoms are useless and everyone should raw dog it in the face of AIDS.

The preventative effects of condoms are impressive, while the drawbacks (both first- and second-order) are relatively small.

Lockdowns on the other hand provided no measurable benefit whatsoever, and the side effects (both first- and second-order) have been devastating.

This is an unserious comparison.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#68
post #15

Earlier quoted context omitted.

[flagged]

Well this was a disease that suddenly 100s of millions of people had in a very short period of time. Ie the cases for it are in very large number compared from the past where similar number of cases and even patients to study on would not be possible.

Sure, but when data did become available (eg, the diamond princess dataset), most reasonable scientists changed their minds. The policies however did not change, and instead continued down a non-evidentiary path.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#69
post #55

Earlier quoted context omitted.

For profit by those who it benefited, namely medical companies who made the so called vaccine. Only by changing and relaxing the long standing criteria for what constitutes a vaccine.

In what way are they not a vaccine?

Before 2020, vaccines referred to things like attenuated viruses - you were basically being given a small weakened dose of the actual pathogen to prime your immune system. mRNA shots are a different animal and they are quite new.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#70
post #66
post #41

Earlier quoted context omitted.

Yeah, it's a rebranding of what we used to call "post-viral fatigue" or "post-viral syndrome", except specific to this one virus.

Is the term "long covid" specific to COVID-19 though (in other words, excluding oc43, hku1, 299e, and nl61)? Or does it mean "long coronavirus disease", including all covids? I see it being used both ways.

I don't know if it's drifted, but it was created in late 2020/2021 specifically for COVID-19.
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