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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#61

Post by m1keil »

joshuamcginnis wrote: post #28
crooked-v wrote: post #18

Earlier quoted context omitted.

Plenty of people have lifelong drug use of, say, caffeine, or aspirin as a blood thinner, or various antihistamines. Why is this somehow worse? Particularly keeping in mind that it's very easy to make, so once the patents expire, it's going to be dirt cheap as generics everywhere.

I'm just sharing my personal preference and not trying to tell people how to live their lives. I don't like personally like the idea that I'll only be healthy if I take this drug for the rest of my life when I could (again - speaking for me), be more disciplined about the food I put into my body.

Why this has to be all or nothing?

You can use the drug to loose weight while trying to understand the underlying problem.

Re: What Ozempic does to the gut-brain axis

#63

Post by kolinko »

rubicon33 wrote: post #8
randycupertino wrote: post #4

Earlier quoted context omitted.

I'm on GLP-1 and it's completely stopped my urge to online shop. I used to browse/shop for fun and out of habit or when I was stressed out or wanted a treat etc. Entirely resolved! I've also lost 40lbs on it.

Do you honestly believe in the so called “free lunch”? I mean there are MANY substances you can presently take that make you feel way better, but always come with a cost or a downside. Why should we believe GLP-1 class drugs are any different?

The point of modern mefivine is that we have drugs that have benefits that outweigh risks and downsides.

Re: What Ozempic does to the gut-brain axis

#64

Post by 9x39 »

y-curious wrote: post #6

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

That says more about the harmful effects of obesity than anything.

Re: What Ozempic does to the gut-brain axis

#65

Post by SubiculumCode »

joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

And this morning, I cut another hole in my belt. Turns out, losing weight and being thin was never about willpower or laziness in the face of absolute food abundance. It was mostly about whether a person was born lucky enough to have a moderate appetite, or was born burdened by exaggerated appetite.

The underlying issue is physiological food cravings, not some personal failing or lack of willpower, and GLP-1 absolutely addresses those "underlying issues". That it isn't some one and done pill is hardly a realistic expectation as that would require probably genetic and epigenetic reprogramming.

Re: What Ozempic does to the gut-brain axis

#66

Post by incognito124 »

sph wrote: post #44
y-curious wrote: post #6

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

Very weird (or funny?) to use statins as an example of a ‘good and effective’ drug.

Why do you say that? My first exposure to statins was in https://myticker.com and they seem somewhat important

Re: What Ozempic does to the gut-brain axis

#67

Post by vidarh »

brazukadev wrote: post #43
vidarh wrote: post #29

Earlier quoted context omitted.

Given that we know that diets and changing habits doesn't have lasting effects, what doesn't sit well with me is to risk my health to avoid taking a drug that helps.

changing habits do have lasting effects, I'm not part of this "we" that doesn't know that.

If you succeed at changing your habit, it works.

However, all the evidence is that the vast majority of people fail at changing their habits in ways that produce lasting weight loss, so it does not generally work as advice for reducing your weight.

So you're technically right, but it is irrelevant, because we don't know how to actually get people to change habits with any meaningful rate of success.

At this point it is downright harmful and wildly unethical to recommend it when we now have a far more successful option.

Re: What Ozempic does to the gut-brain axis

#68

Post by aaron695 »

joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

[dead]

Re: What Ozempic does to the gut-brain axis

#69

Post by saberience »

crooked-v wrote: post #59
joshuamcginnis wrote: post #26

Earlier quoted context omitted.

I think there's a distinct difference between taking medicine for things you can fix on your own (diet + exercise) vs things you cannot (excess acid production).

I'm not on GLP-1s, but I've been looking at very seriously because something I can't "fix on my own" is just... always feeling hungry. That's just how my body works. Exercise doesn't help; there's no reasonable amount of exercise that will help with my office-worker stomach wanting 3000 calories a day. So far through my life I've just lived with it and managed my diet as best I can and it just absolutely sucks.

[flagged]

Re: What Ozempic does to the gut-brain axis

#70

Post by yakz »

topgrain2 wrote: post #58
brazukadev wrote: post #43

Earlier quoted context omitted.

changing habits do have lasting effects, I'm not part of this "we" that doesn't know that.

People talk past each other on this because for an individual it technically can work, and sometimes does, but on a population level, as extensively studied by people whose job it is to study that, it definitely does not work. Even with tons of regular attention from professionals and a cohort selected to have above-average motivation, it’s surprisingly poorly-performing (and that’s a crazy expensive level of interve…

I think it'd be more accurate to say that informing people that they should change their behavior doesn't work. A person changing their behavior can escape obesity. The reality is that most people won't be able to change their behavior without some other kind of assistance.
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