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MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

sciencedaily.com

61–70 of 108 posts

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#61

Unfortunately, I will probably never be able to try that for my GAD even if they confirm the positive effects due to stigma surrounding psychoactive drugs! Yay!

psilocybin is easy to find (even legally, in certain jurisdictions) or cultivate yourself.

LSD and psilocybin are very different. Wouldn't think it, but it's true

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#62
post #12
post #5

It seems like every few weeks there's an article on how drugs are amazing hitting the front-page.

Where do you go when you need to escape but can't actually go anywhere? Inwards. Imagination, media, substances, meditation, solitude.

To an extent I feel your position, and it can be true in many contexts. I would say, however, that taking a trip to a far off country, and dropping acid serve two different purposes. While I'm sure there's some overlap, you won't get the entirety of the experience from either one exclusively.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#63
post #53

I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have…

I think curing GAD will mean changing your personality. There's always going to be a before/after you, that's the whole point. The important part is being able to reliably know what the "after you" will be so you can be sure that you want that change to happen.

Curing anything changes your personality. I stopped biting my nails to the quick after 50 years - that's a difference!

The Ship of Theseus argument should never be used to justify retaining mental dysfunction. "What if I can't paint sunflowers if I stop being suicidal?" is a question; more decades of Van Gogh paintings would inarguably have been better.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#64

"Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves. Here's Tom with the weather." -Bill Hicks

today an evolved monkey realized that the evolution of intelligence via genetic algorithms doesnt line up that well with the scientific trajectory of existence since the big bang , he then realized that his perception of existence would be exactly equivalent to that of a brain in a jar , his final realization was that all realizations are epheremal regardless as to how convincing or conclusive they may seem

Hell yeah man. Momentary lapse.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#65

Unfortunately, I will probably never be able to try that for my GAD even if they confirm the positive effects due to stigma surrounding psychoactive drugs! Yay!

Why? Stigma from whom?

MM120 is seeking FDA approval and there are many more in late stage trials for GAD.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#66

This reflects a longstanding...essentially conspiracy...to suppress attention to 5HT2A-based neural regulation because it sheds such poor light on SSRIs

I land on "if it helps it helps."

But if you catch me in a get-together setting and we share a beer together, I'd say: "on the one hand you have a well-determined profitable path in the SSRIs, and on the other hand you have people giving LSD doses away for free to each other. One sits well, one doesn't. One has to wonder why the people aren't giving away SSRIs for free if they work so well, right?"

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#67
post #23
post #5

It seems like every few weeks there's an article on how drugs are amazing hitting the front-page.

HN has some peculiar medical fixations. It comes in waves. For a while there were a lot of submissions about intermittent fasting. 15 years ago people were excited about polyphasic sleep. 10 years ago it was all about modafinil. Enthusiasm about ketamine for depression was big, but it seems to have finally fizzled out.

Ketamine is still used for depression quite effectively.

It's good that techbros' interest in it fizzled out though. Better for everyone that way.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#68
post #35

Earlier quoted context omitted.

Why can't they just put it in the title of the article instead of classic clickbait tactics? Ugh.

I agree. I have anxiety sometimes, but I’m not about to start taking LSD. I’m not going to risk a permanent psychological crisis to reduce my anxiety. It’s not really a cure if it has a even a small percentage chance of causing something much worse.

Fair point. You know your body the best and should be the final arbiter of what's ingested. Side point and question: Can't SSRIs cause Serotonin Syndrome? Doesn't the reduction of anxiety come with a small percentage chance of causing something much worse?

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#69

"Side effects were mild or moderatr and included hallucinations..." Yeah....

No. That is a gross and deliberate mischaracterization in bad faith. Here is the full quote: > Side effects were generally mild or moderate and included hallucinations, visual distortions, nausea, and headache. It's important to note, these were more prevalent using the highest dosage -- which we will not be using since it was found to be no more effective.

More prevalent, not absent. As I understand it, anything that affects the 5HT2A receptor will induce a psychedelic state. Magnitude being dose-dependent.

Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)

#70

I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have…

My experience was similar, with social anxiety suddenly removed it made me a bit of a dick for a while.
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