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Drug trio found to block tumour resistance in pancreatic cancer in mouse models

drugtargetreview.com

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Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#61

Post by huhkerrf »

A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

Things are, at least, getting better with the passage of right to try laws: https://en.wikipedia.org/wiki/Right-to-try_law

These drugs seem to all be only allowed after Phase 1 trials, so still not quite at the level you're describing here.

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#62

Post by braedonwatkins »

m463 wrote: post #44
jonshariat wrote: post #2

I've been playing to much pokemon with my kids, read this as "Dugtrio"

there must be some sort of word for "games-bleeding-into-real-life" for stuff like this. I remember years ago playing some games, and hearing similar sounds in real life would startle (or amuse) me. And you can't really explain it to anyone around you, lol.

tetris effect! https://en.wikipedia.org/wiki/Tetris_effect

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#65

Post by [deleted] »

petcat wrote: post #60
bobbylarrybobby wrote: post #56

Earlier quoted context omitted.

That's not what the prisoner’s dilemma is.

Yeah this is more like a Pascalian Gamble [1]. If you try nothing, then you are assured to die as God wanted. If you try something , then you might live, but then God hates you. [1] https://en.wikipedia.org/wiki/Pascal%27s_wager

[deleted]

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#66

Post by WinstonSmith84 »

A_D_E_P_T wrote: post #47

> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…

I had a relative who died from this around 20 years ago. 50yo slim, sportive and healthy and after going to a diagnostic as she didn't feel good, she was gone within a few months .. So yeah, if there is even a slight chance it works, this should be tried and that'd save people :(

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#67

Post by bluGill »

Tade0 wrote: post #57

Recently YouTube again started recommending to me channels of people who died of cancer. I looked at a clip of a man just a few years my senior where he was describing the symptoms that in his view should have made him go see a doctor earlier, because maybe then his pancreatic cancer wouldn't have been fatal. Truth be told they wouldn't raise any red flags if I had them. Only thing that I'm doing differently is havin…

That is the problem with symptoms in general. Most people who go to the hospital with "chest pain" are not having a heart attack - but it is still the best symptom we have and so emergency rooms "waste" a lot of time one people who have nothing wrong. Or more likely they just have a mild constipation case (look up constipation, and then look up the individual symptoms - most of them are also symptoms of GET TO THE ER NOW type things)

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#68

Post by jjtheblunt »

tansey wrote: post #34

For all the folks complaining about "it's only in mice! things never work in humans!" -- I work at MSK and we definitely have seen success treating PDAC in humans: https://www.nature.com/articles/s41586-023-06063-y "Why don't I see these treatments hitting the general public?" Because trials like these are phase I/II. Then you need a phase III that takes a long time to recruit a large cohort and has overall survival…

What's MSK?

Re: Drug trio found to block tumour resistance in pancreatic cancer in mouse models

#70

Post by wormius »

Am I misunderstanding the headline? Is the word "block" now meaning "enhance" instead of "stop"? I would think based on the text of the article that it enhances resistance. Or are tumors necessary to stop cancer growth (even though it is cancer growth?)
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