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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#61

Post by jvanderbot »

stronglikedan wrote: post #45
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

> Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. As an American with a sister with thyroid issues, I can say that is absolutely not true for the majority of Americans. People are mostly sympathetic to those who are not obvious slobs.

With respect, neither of you are qualified to speak for majority of Americans, but given the amount of effort, money, ink, and television dedicated to looking better and losing weight combined with the fact that there's even a thing called fat phobic that even requires definition just to push back on all that...

I think there's sufficient reason to believe that "Overweight = bad" is a common standard that at least people hold themselves to.

Re: Ozempic shows anti-aging effects in trial

#62

Post by [deleted] »

neves wrote: post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

[deleted]

Re: Ozempic shows anti-aging effects in trial

#64

Post by naravara »

noah_buddy wrote: post #20
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

The weight loss mechanism largely just comes from suppressing appetite though, so it still lines up with the penance for sin narrative. It’s not that different from wearing a hair-shirt and whipping yourself if you find yourself having lustful thoughts. Only instead of a whip you just feel kind of uncomfortable and nauseous if you eat too much.

Re: Ozempic shows anti-aging effects in trial

#65

Post by smiley1437 »

hollerith wrote: post #28
some_random wrote: post #24

Earlier quoted context omitted.

I think that's a completely reasonable concern to have, it doesn't seem to be the case wrt obesity but for the myriad of other potential effects it's important to keep in mind.

I'm not even ready to concede that it is a good weight-loss drug -- but then I haven't really investigated much, so I'm just repeating what I heard from researcher Ben Bikman and maybe other researchers. I heard that most people choose to discontinue it after 4 or 5 years or less, regain most or all of the weight, then refuse to go back on it.

Tirzepatide (and likely other GLPs) have limitations that are rarely brought up in the general media

- Patients have about 72 weeks to reach maximum loss, they don't lose any more weight after 72 weeks even on the highest dose.

- Patients appear to immediately gain the weight back as soon as they stop taking it.

It's right in the phase 3 trial outcomes paper:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10667099/

I suspect that this info is intentionally down-played so that it doesn't affect sales.

Re: Ozempic shows anti-aging effects in trial

#66

Post by mapontosevenths »

throwforfeds wrote: post #31
hollerith wrote: post #28

Earlier quoted context omitted.

I'm not even ready to concede that it is a good weight-loss drug -- but then I haven't really investigated much, so I'm just repeating what I heard from researcher Ben Bikman and maybe other researchers. I heard that most people choose to discontinue it after 4 or 5 years or less, regain most or all of the weight, then refuse to go back on it.

I've had a few friends on it. They definitely lost weight, but the GI issues were too much and when they went off of it they gained it all back.

> when they went off of it they gained it all back.

To make matters worse, even ibuprofen is a scam. I stopped taking it and my headache came right back!

More seriously, if you stick to it the GI issues go away after the first month for most people.

Re: Ozempic shows anti-aging effects in trial

#67

Post by kulahan »

cm2187 wrote: post #57
noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. RFK Jr's "let them eat less" is paradoxically the modern version of "let them eat cake"!

I think many people confuse simple with easy.

It IS simple to reduce your weight. There are like, two things you need to do. It is, however, VERY hard to actually do those things.

Re: Ozempic shows anti-aging effects in trial

#68

Post by matwood »

jjice wrote: post #54
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

Re: Ozempic shows anti-aging effects in trial

#69

Post by YokoZar »

kjkjadksj wrote: post #26
pitpatagain wrote: post #11

This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

It varies. People are often thinner in their twenties than their thirties and forties. If you browse some before and after pictures the ones who have had their skin tighten tend to look younger for that reason alone.

Re: Ozempic shows anti-aging effects in trial

#70

Post by sharkjacobs »

wolfi1 wrote: post #22

Is the term "biological age" even well defined?

Presumably it is in the narrow context of the study, since they need something they can consistently measure and compare

> The researchers used epigenetic clocks to assess biological aging - sophisticated tools that identify patterns of DNA methylation, chemical tags that affect gene activity and shift predictably with age

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