Why do people take multivitamin any how?
I eat the exact same meals every day. Without a multi-vitamin I'd likely get some sort of vitamin/nutrient deficiency, I imagine.
Lol, poor you.
High vitamin B6 doses over a long period could cause irreversible nerve damage
61–66 of 66 posts
Re: High vitamin B6 doses over a long period could cause irreversible nerve damage
#62Earlier quoted context omitted.
I mean, you could take a blood sample and send it to a lab, at least once? But I'm curious what the easiest way would be.
My life improved immensely after B6 supplementation, never once has a blood test shown I am deficient.
It might still be a good idea to check if your level is now too high ...
Re: High vitamin B6 doses over a long period could cause irreversible nerve damage
#63Earlier quoted context omitted.
I've been taking "Opti-Men" from Optimum Nutrition for like 10 years now and it seems to have 50mg in a (full) serving that I take. Since B6 is water soluble doesn't it mean most of it might just leave our body if not needed? (No storage in fat)
This is the mechanism of action: Vitamin B6 is an antioxidant and coenzyme involved in amino acid, carbohydrate and lipid metabolism. Humans cannot directly produce active vitamin B6 (pyrixodal phosphate). However, salvage pathways allow the enzymatic conversion of vitamin B6 vitamers, including pyridoxine, pyridoxal and pyridoxamine by the enzyme pyridoxal kinase, into active vitamin B6. In the body, active vitamin…
Can you boil this down for us? Does or does not B6 accumulate in the body?
Re: High vitamin B6 doses over a long period could cause irreversible nerve damage
#64Earlier quoted context omitted.
> Cases of toxicity have been reported at doses as low as 21 mg per day, the recommended daily intake is 1.3 to 2 mg. The person in question was diagnosed with issues possibly caused by this after 2 years. That's very hard to believe. In my "normal" vitamin B-Complex supplement there is 20mg of B6 in the daily dose. If 21mg per day would cause nerve damage, that we'd know (and it would be an epidemic).
I've been taking "Opti-Men" from Optimum Nutrition for like 10 years now and it seems to have 50mg in a (full) serving that I take. Since B6 is water soluble doesn't it mean most of it might just leave our body if not needed? (No storage in fat)
I agree, as B6 is water soluble, it should be fine to take more, the body just gets rid of it.
Re: High vitamin B6 doses over a long period could cause irreversible nerve damage
#65Happened to me, took me three years to fully recover. After 2.5 years my blood test was FINALLY showing levels under the top of the range for B6 serum. At the worst I had full body muscle spasms that would go on 24/7, all the big and tiny muscles in my arms, face, legs. The worst however was I had esophageal spasms constantly which I confused for heart issues for the longest time. I completely lost feeling in my fingertips and toes. The list goes on.
In all though I had pretty much every symptom listed here: https://understandingb6toxicity.com/b6-toxicity/symptoms/
It's actually pretty crazy, I tested recently because I was curious and for the first time since I completely stopped B6 I took a 10mg dose and that evening my muscle spasms came back, my nervous system is so whacked out from this. This experience is what turned me off from supplements, it's horrible.
Re: High vitamin B6 doses over a long period could cause irreversible nerve damage
#66Earlier quoted context omitted.
This is the mechanism of action: Vitamin B6 is an antioxidant and coenzyme involved in amino acid, carbohydrate and lipid metabolism. Humans cannot directly produce active vitamin B6 (pyrixodal phosphate). However, salvage pathways allow the enzymatic conversion of vitamin B6 vitamers, including pyridoxine, pyridoxal and pyridoxamine by the enzyme pyridoxal kinase, into active vitamin B6. In the body, active vitamin…
Can you boil this down for us? Does or does not B6 accumulate in the body?
Even though it is water soluble, yes it can accumulate, especially at the higher doses found in supplements. The primary way this happens is via unaware supplementation. Usually people are unaware that their product contains b6 - it's in a lot of products that are not advertised to contain it.
So even though it is water soluble it can still accumulate when taken at these high doses. Most supplements contain pyridoxine, which can acumulate and damage peripheral nerves. Indeed the form of B6 is important, and manufacturers take advantage of the fact that consumers (and medical practitioners) are unaware of the difference. Taking P-5-P may be less risky than pyridoxine hydrochloride, a cheaper option that is included in most supplements.