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Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

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Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#61

Post by Ey7NFZ3P0nzAe »

dreamcompiler wrote: post #51
porphyra wrote: post #43

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

It's terrible that you are counting in tablets instead of actual amount of acetaminophen

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#62

Post by dogtorwoof »

dreamcompiler wrote: post #51
porphyra wrote: post #43

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

You die from liver failure. Which is a horrible way to die. You’re bleeding and clotting at the same time. Your abdomen swells with fluid. Then your legs and your whole body. Your skin turns yellow and you’re itching constantly. You become increasingly confused and violent. Infections start brewing in that pool of fluid in your abdomen.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#63

Post by w10-1 »

snibsnib wrote: post #46

I'm not an expert in pharmaceutical chemistry, but this looks like a series of relatively complex and low yield reactions. Would it be likely that this would push the price of this product beyond what is reasonable for a general use drug?

If it makes it to market at a high price, it wouldn't compete directly but be targeted to those at risk of toxicity.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#64

Post by Ey7NFZ3P0nzAe »

MichaelRo wrote: post #54
reedf1 wrote: post #44

Earlier quoted context omitted.

I take it mostly as an anti-pyretic (fever reducer). For which it is extremely effective. It's my drug of choice for colds, flu, etc.

Well, it doesn't work for high fever (> 39-40 Celsius). For that, I alternate Ibuprofen and sodium metamizole every 4 hours. For pain release, paracetamol it's very modest. Some effect for light head pain, zero for strong pain. Zero effect for strong back pain. Ibuprofen works better in all these cases but comes with stomach damage if taken for long.

Paracetamol is nicely synergic with all known painkillers. For example prescribing it with morphine leads to less morphine consumption.

Also: it's a terrible rule of thumb to take an NSAID routinely for general infectious symptoms like fever.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#66

Post by andai »

dogtorwoof wrote: post #62
dreamcompiler wrote: post #51

Earlier quoted context omitted.

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

You die from liver failure. Which is a horrible way to die. You’re bleeding and clotting at the same time. Your abdomen swells with fluid. Then your legs and your whole body. Your skin turns yellow and you’re itching constantly. You become increasingly confused and violent. Infections start brewing in that pool of fluid in your abdomen.

I am going to cancel my internet subscription...

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#67

Post by Jolter »

porphyra wrote: post #43

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

But how many cases of poisoning occur each year?

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#68

Post by mulderc »

Jolter wrote: post #67
porphyra wrote: post #43

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

But how many cases of poisoning occur each year?

“56,000 emergency department visits and 2600 hospitalizations, acetaminophen poisoning causes 500 deaths annually in the United States” -Acetaminophen Toxicity Suneil Agrawal; Brian P. Murray; Babak Khazaeni. https://www.ncbi.nlm.nih.gov/books/NBK441917/

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#69

Post by hgomersall »

Ey7NFZ3P0nzAe wrote: post #61
dreamcompiler wrote: post #51

Earlier quoted context omitted.

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

It's terrible that you are counting in tablets instead of actual amount of acetaminophen

It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#70

Post by whymauri »

porphyra wrote: post #43

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

acetaminophen should not be an OTC drug
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