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Psilocybin desynchronizes the human brain

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61–70 of 276 posts

Re: Psilocybin desynchronizes the human brain

#61
post #12

While the analogies are often useful, everyone reading HN comments should be very aware and very skeptical of just how often computer/tech people rely on computer/tech analogies to understand things that are fundamentally not computers/tech. It is very very easy for smart people with functionally specific jobs/hobbies/ways of thinking to see all reality through that narrow window. It often leads to important details…

Feeling "it is just a feeling" is also just a feeling.

Actually we overload the word "feeling" to include thoughts and perceptions which are not feelings. Like "I feel sad" is a feeling. "I feel like you are being a jerk" is not a feeling it is a thought or perception.

Re: Psilocybin desynchronizes the human brain

#62

Earlier quoted context omitted.

[flagged]

Around 1% of people have schizophrenia. This holds over a lifetime - there's a structural, unavoidable component to the person's neural wiring or physiology that will result in a schizophrenic break. Prior to the break, they may seem more or less normal, but after, they will experience deficits in cognition and perception, and may have significant barriers to living a normal life. Schizophrenics, as a rule, will have…

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Re: Psilocybin desynchronizes the human brain

#63
post #59

Earlier quoted context omitted.

At least 42% of Americans live in a household with a gun so it isn't particularly useful to write off the anecdote.

This percentage is much smaller in other countries, so actually it is... if you don't live in the USA, which is a large majority of the world's population.

Many countries in Europe have tons of older hunting guns, on top of newish guns for... personal protection? Sport? Or whatever reason people feel the need to have them.

Tens of millions as per wikipedia [1]. Also check other countries and continents. A very valid argument.

[1] https://en.wikipedia.org/wiki/Estimated_number_of_civilian_g...

Re: Psilocybin desynchronizes the human brain

#64

PSA: My buddy shot himself in the head while we were on shrooms in our twenties. He thought he meant God, took a shower picked up a gun and shot himself in the head. While I've had trips since then and do get benefits from those experiences. People without experience should be careful, especially if you have a history of mental illness. He did have a history to some degree but not overtly.

Thanks for sharing. Not sure if the guidance to do shrooms in an appropriate setting and with an appropriate mindset ("set and setting") would have helped, but certainly that guidance is no joke!

And we should absolutely continue research to learn more about the adverse effects. Obviously they help a lot of people, but must be done with care and seem not to be helpful for every person. We must learn more about these conditions.

Re: Psilocybin desynchronizes the human brain

#65

[flagged]

It can also induce a psychological break and/or acute schizophrenia and/or lasting distortions of perception, so maybe cool it with the unwarranted medical advice

Well I'm not a doctor. I'm a random commenter with an opinion on the internet. I would recommend people not take "medical advice" from people they don't know. I'm not going to stop sharing my opinion, though.

Re: Psilocybin desynchronizes the human brain

#66

I can't think of anything in the world I would enjoy doing less than completing "a simple auditory–visual matching task" while in an MRI scanner on shrooms.

The set and settings researchers typically use for usual psych studies are going to bias psychedelic results so much. Think that building you hated in undergrad's crusty unlit cinderblock basement with no windows but coated in cameras and microphones. Its so dystopian, you are literally a caged rat. I don't think you can perform this research in good faith without having experienced a proper trip yourself. It's just impossible to put into words much less gleam any actual understanding from written description of it.

Science needs more Albert Hoffman's who are willing to couple their knowledge with this experience without fear of being fired from IRB violation and ostracized by the scientific community. Otherwise we will forever be grasping in the dark with these drugs.

Re: Psilocybin desynchronizes the human brain

#67

PSA: My buddy shot himself in the head while we were on shrooms in our twenties. He thought he meant God, took a shower picked up a gun and shot himself in the head. While I've had trips since then and do get benefits from those experiences. People without experience should be careful, especially if you have a history of mental illness. He did have a history to some degree but not overtly.

Thanks for that PSA. And here's to your lost friend!

I have a lost one too, but due to a different cause. He took hard drugs he was dealing to pay off a house after a legislative decision basically eliminated his well paying job. We grew up very much do what it fucking takes kind of people. And we were tested in life more than once. I still draw from that time today, sometimes remembering and finding that which will get me through. I miss him terribly.

Had he not used, he would have made it! We talked about that, and he used "a little" to know better what he was dealing. Now we all make choices and he made his. At the time, financially, it was understandable, though I would have chosen differently myself.

Anyhow... hard lessons!

Lost him in my very early 30's and I think of him regularly, as I am sure you do yours. What got him was the loss of autonomous breathing! Yes, right out of Greek mythos, he suddenly had to breathe consciously after a particularly nasty interaction with some of the product and his physiology.

It truly was a curse. Bit by bit, he lost the fight. Was cruel and hard to watch.

Sidebar: I am angered and lament the timing because I very strongly feel some form of electrical stimulation could have helped. I lacked means at the time. We both really wanted to try. Doctors had nothing.

End sidebar.

These drugs have awesome potential, but they also come with considerably greater risks than many of us know too.

Good PSA. Seconded.

Be careful peeps. We think we understand. Fact is we just don't yet.

And that will improve with proper study using the scientific method.

If you ask me, cutting those risks is the single most powerful argument for permitting ongoing research and study of the powerful things left for us in Mother Natures kitchen.

Re: Psilocybin desynchronizes the human brain

#69

PSA: My buddy shot himself in the head while we were on shrooms in our twenties. He thought he meant God, took a shower picked up a gun and shot himself in the head. While I've had trips since then and do get benefits from those experiences. People without experience should be careful, especially if you have a history of mental illness. He did have a history to some degree but not overtly.

Part of the lesson of this story is the danger of having a gun in the home at all. He could have been sober and depressed and did the same just as easily thanks to having access to a gun. There's a lot of statistical evidence for how dangerous situations like depression or domestic violence can become once a gun is nearby.

Re: Psilocybin desynchronizes the human brain

#70

[flagged]

Do you know similar stuff about dissociatives, like NMDA-antagonists? Are their effects in any way comparable or is it completely different net results?

I have no experience with those, to be honest. But I feel like they have a similar effect. Considering Ketamine is used for similar purposes.
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