In terms of installations, sure. In terms of total data, probably not. In terms of important data, 100% not. Important data needs guarantees, and its privacy is second to its longevity. Server side and centralized beats client side decentralized for all but sensitive consumer data.
I'm not sure I buy the "important data" one: my Lightroom catalog, to me , constitutes incredibly important data. Losing it and just having the base files would destroy over a decade of work. It also happens to be a SQLlite3 database. And the same is true for a slew of other applications that (quite rightly) use SQLite databases as their file format. You might be thinking of things like financial transactions, or med…
I venture a guess that for each sqlite db holding important work data, you have dozens or hundreds of traditional db datasets, that are critical to your work. And yes, I mean your bank, but also messaging apps, online services.
If you backup your hard drive in the cloud at all, you are already depending on trad dbs for the very use case supposedly highlighting your dependence on sqlite.