Earlier quoted context omitted.
Decades ago, about 30% of the people who had celiac disease would waste away and die, especially children. Until a doctor noticed that if the people ate 12 bananas a day they seemed to do better. Of course, 12 bananas a day is a kooky diet, but people who eat 12 bananas a day tend to eat less of everything else, including less bread and gluten and so they would do better. Later science figured out bread was a problem…
>I think there are other foods that bother different people, but we haven't managed pin down exactly which foods bother which people. It's a hard problem Sounds like a job for a neural net. If people would log all what they eat and how they feel. If the neural net had access to all the components of the foods they are inputting, surely with enough data a pattern would emerge of what common component in what they eat…
First-in-human implantation of bionic device to halt Crohn's disease (2023)
61–70 of 129 posts
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#62Earlier quoted context omitted.
I will just call my assistant to get the jet and shack ready in the Hamptons, and to cancel all my meetings!
This is a logical fallacy argument where you exaggerate. What I describe can be done in most locations, no Hamptons needed.
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#63I initially wrote this as a reply to a comment by "NotGMan" mentioning fasting/paleo that got flagged. They could have approached the subject more delicately but I believe they have a point. About 3 years ago I had gut issues so bad I thought I was close to death. NHS couldn't see any problems and were basically telling me I'd gone nuts. They refused to do any further testing. After a year of suffering I tried a 7 da…
I recall on an ask reddit a group of gastroenterologists were answering questions. One thing that stood out was they said "let your stomach rumble it's a necessary part of gut health". Fasting would help initiate that, but I think so many people these days never stop eating long enough for their stomach to rumble.
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#64Earlier quoted context omitted.
All of them increase risk of cancer (EDIT: upon further review, maybe not all of them? Or maybe just with combination therapy?) and severe infection. Many of the biologics are also quite new, and the long term effects of taking them are not well understood. Plus, in some cases they don't work well enough alone and so multiple drugs are required (a biologic in combination with something like methotrexate or azathiopri…
I mean if you’re thinking about the big picture, chronic inflammation increases cancer risk even more. For corticosteroids, I agree… But that’s not supposed to be used long term and is a bit of an emergency resort.
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#65Earlier quoted context omitted.
All of them increase risk of cancer (EDIT: upon further review, maybe not all of them? Or maybe just with combination therapy?) and severe infection. Many of the biologics are also quite new, and the long term effects of taking them are not well understood. Plus, in some cases they don't work well enough alone and so multiple drugs are required (a biologic in combination with something like methotrexate or azathiopri…
At least for Ulcerative Colitis, there are safe drugs that are much less effective (mesalamine) but the strong effective drugs all come with long-term cancer risks (prednisone, remicaid, entyvio, etc), as you say. The newer drugs like entyvio are generally less risky than the older ones, mostly on account of being more targeted, but the risk is still significant. I imagine the situation is similar for CD.
I got Pneumonia that turned into Sepsis in about 60 hours. It happened so fast that the doctors brought in an addiction specialist. The only other time they’ve seen this is when drunks pass out and aspirate on their vomit. (Crohn’s doesn’t let me drink, so we can rule that out…) After days of studies, we found the warning label on Stelara about the elevated risk of lung infections. My care team reached out the Janssen and confirmed it. After about 4 days of IV antibiotics, I was sent home to continue on oral antibiotics.
Still, if I die from something like this, it’s still worth it to take these biologics. At least I lived a much better life for a while thanks them. The side effects can be life threatening, but the ability to have a life is worth it.
TLDR: On Stelara, I went from Pneumonia to Sepsis in about 60 hours while taking oral antibiotics. The warnings on the labels of the biologics are serious - and the side effects can be life threatening.
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#66Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#67Earlier quoted context omitted.
Rinvoq?
That is one she has been on in the past. She has gone thru about 8 trying to find one that works best for her. She is currently on tremfya
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#68Earlier quoted context omitted.
Which drugs are you talking about? Pretty much all the biologics for CD have amazingly positive safety profiles…
some of them you have to take with an immunomodulator to suppress the possibility of antibodies, and those increase the risks of lymphoma and some other stuff.
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#69We have so many "bandaids" but very few cures these days. Perhaps AI systems will allow us to find root causes of these insidious diseases.
Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)
#70Earlier quoted context omitted.
Which drugs are you talking about? Pretty much all the biologics for CD have amazingly positive safety profiles…
All of them increase risk of cancer (EDIT: upon further review, maybe not all of them? Or maybe just with combination therapy?) and severe infection. Many of the biologics are also quite new, and the long term effects of taking them are not well understood. Plus, in some cases they don't work well enough alone and so multiple drugs are required (a biologic in combination with something like methotrexate or azathiopri…
Plus—you have a chance of beating cancer. But a colectomy is a one-way trip!
(Prednisone will absolutely fuck you up long-term though. No cancer risk afaik, but osteoporosis risk is through the roof. I've heard of UC patients who needed joint replacements in their 30s from long-term steroid use...)