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Brain waves appear to wash out waste during sleep in mice

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Re: Brain waves appear to wash out waste during sleep in mice

#61
post #38

Earlier quoted context omitted.

Checked and it was published through Nature: Jiang-Xie, LF., Drieu, A., Bhasiin, K. et al. Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance. Nature 627, 157–164 (2024). https://doi.org/10.1038/s41586-024-07108-6 Every Uni should have access through your library system.

Yes, it was published through Nature. But what stops Univ' site to have original research paper available for download? Nature magazine is just a distribution channel (they did not sponsor the research so should not have exclusive rights on it). Left college long time ago; and do not have access to any library system.

Copyright Transfer Agreement. The moment you send the paper to Nature, you can only publish the draft you sent in. Unless you pay for publish, editorial costs are paid by selling access to that paper.

If you want to publish in an Open Access manner, you need to pay the costs. Or if your country wants to license it for Open Access, your country pays the costs.

Re: Brain waves appear to wash out waste during sleep in mice

#62
post #47
post #37

Earlier quoted context omitted.

I think the point was that every member of the public should have access to publicly funded research at least through the university's website, rather than at least everyone currently in universities should have access.

I agree but I also know (as a university employee) that the reason they don’t do this is because then they would have to pay for and manage the hosting of hundreds of thousands of articles. From the university’s perspective, managing and hosting articles is exactly what publishers do, so universities cede that work to publishers. What is needed is a public database of all publicly-funded research.

Sounds like a good cost for the government to subsidize.

Re: Brain waves appear to wash out waste during sleep in mice

#63
post #38

Earlier quoted context omitted.

Yes, it was published through Nature. But what stops Univ' site to have original research paper available for download? Nature magazine is just a distribution channel (they did not sponsor the research so should not have exclusive rights on it). Left college long time ago; and do not have access to any library system.

If you email the authors they might be happy to send you a copy - scientists tend to be in favour of the free exchange of information, there's no restriction on them sharing their paper if they choose to, and they don't get royalties from journal subscriptions so they have no vested interest in paywalling their research

Not all of them. I sent a couple of such mails, to only get back the freely available summary PDFs back. Even with the same checksum with the ones on the web.

Re: Brain waves appear to wash out waste during sleep in mice

#64
post #31

Earlier quoted context omitted.

>Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Sounds like unsync'd brain waves, (being awake) impedes cerebrospinal fluid flow through the brain. When asleep, neurons sync their action potentials, acting like a ionized fluid pump, moving old dirty cerebrospinal fluid out, and allowing new, clean in.…

I wonder if this state could be ultrasonically induced to have a "sleep helmet" which can calm and align rhythmic waves? and induce an artificial flush or "power nap" -- Well, thats basically the trope of every Cybernetic design, with the connectors comming out the back of head/spine... Like a continual wash which keeps you in this suspended hyper-aware, but calm, rested and focused mental state. This is why cyborgs…

I was thinking if we could directly tap and pump fresh cerebrospinal fluid and eliminate sleep

Re: Brain waves appear to wash out waste during sleep in mice

#65
post #47
post #37

Earlier quoted context omitted.

I think the point was that every member of the public should have access to publicly funded research at least through the university's website, rather than at least everyone currently in universities should have access.

I agree but I also know (as a university employee) that the reason they don’t do this is because then they would have to pay for and manage the hosting of hundreds of thousands of articles. From the university’s perspective, managing and hosting articles is exactly what publishers do, so universities cede that work to publishers. What is needed is a public database of all publicly-funded research.

How hard or expensive is it to embed a PDF link in the Univ news article. It maybe less harder and expensive than the stock image that they have used.

Stanford maintains an extensive catalog of research papers: https://searchworks.stanford.edu/view/in00000064276

Re: Brain waves appear to wash out waste during sleep in mice

#66
post #38

Earlier quoted context omitted.

Yes, it was published through Nature. But what stops Univ' site to have original research paper available for download? Nature magazine is just a distribution channel (they did not sponsor the research so should not have exclusive rights on it). Left college long time ago; and do not have access to any library system.

Copyright Transfer Agreement. The moment you send the paper to Nature, you can only publish the draft you sent in. Unless you pay for publish, editorial costs are paid by selling access to that paper. If you want to publish in an Open Access manner, you need to pay the costs. Or if your country wants to license it for Open Access, your country pays the costs.

The final draft that was sent is good enough, maybe all that one needs.

Re: Brain waves appear to wash out waste during sleep in mice

#68
post #66

Earlier quoted context omitted.

Copyright Transfer Agreement. The moment you send the paper to Nature, you can only publish the draft you sent in. Unless you pay for publish, editorial costs are paid by selling access to that paper. If you want to publish in an Open Access manner, you need to pay the costs. Or if your country wants to license it for Open Access, your country pays the costs.

The final draft that was sent is good enough, maybe all that one needs.

Sometimes yes, sometimes no. In my case, the edited versions of (my) paper had more experiments, refined images and was more complete.

The paper was not bad to begin with, but the edited/revised version painted a more complete picture which shouldn't be possible without a set of external reviewers.

Re: Brain waves appear to wash out waste during sleep in mice

#69
post #46

We need to figure out what activity or thought creates waves most similar to the cleaning function. Maybe it’s dreaming? Dreaming by my experience is tedious and not restful… I have 4-6 dreams every night and never feel like I’m truly asleep. Shouldn’t be hard to figure out with an EKG and a decent graph to see what your aiming for.

Modafinil does exactly this.

Huh? It cleans the brain? Care to elaborate or provide a source?

Re: Brain waves appear to wash out waste during sleep in mice

#70
post #47
post #37

Earlier quoted context omitted.

I think the point was that every member of the public should have access to publicly funded research at least through the university's website, rather than at least everyone currently in universities should have access.

I agree but I also know (as a university employee) that the reason they don’t do this is because then they would have to pay for and manage the hosting of hundreds of thousands of articles. From the university’s perspective, managing and hosting articles is exactly what publishers do, so universities cede that work to publishers. What is needed is a public database of all publicly-funded research.

some sort of scientific hub, one might say
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