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FDA approves first medication to reduce allergic reactions to multiple foods

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Re: FDA approves first medication to reduce allergic reactions to multiple foods

#61

Post by shwaj »

teen wrote: post #49
yosito wrote: post #42

Earlier quoted context omitted.

> staff at food places can be sometimes less than reliable about food allergy concerns As someone with Celiac disease, who often eats at restaurants, this is a bit of an understatement. Even in restaurants where things are marked allergen free on the menu, it is often the case that staff will make mistakes. More often than not, staff aren't even informed about the basics of food, things like eggs and dairy being two…

maybe you're just allergic to glyphosate, not wheat. glyphosate is in pretty much everything now

This might be true for people in general, but people who have been diagnosed with Celiac disease are definitely allergic to wheat.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#62

Post by roganartu »

sundvor wrote: post #44
8ig8 wrote: post #36

Earlier quoted context omitted.

So hard to believe that this is so complicated. People’s lives and health. I wish it was easier.

Move to Australia? On a script, cost is AUD $31.60 per syringe, a rather stark saving from $410 . I wonder how that latter price compares to the price in the US, I couldn't quite get the prices I read without insurance to compute in my head. https://www.health.gov.au/ministers/the-hon-greg-hunt-mp/med... https://m.pbs.gov.au/medicine/item/10109c-10110d-10118m-1012...

> I wonder how that latter price compares to the price in the US

My guess is not favourably for the US. My wife was diagnosed with MS about a year before we moved to America and, since I knew we were moving and was thinking about insurance, I asked the pharmacist once what they billed the govt per dose (monthly). We paid $40 out of pocket and the govt paid $1300 AUD.

Our insurance in the US pays nearly $10k USD/m for the same drug.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#63

Post by bennyg »

looping8 wrote: post #60
modeless wrote: post #46

Earlier quoted context omitted.

The study lasted 20 weeks, but I believe you have to continue the treatment indefinitely if you want the effects to continue. It's not a permanent fix, and a once or twice monthly injection for the rest of my life is not something I'd like to sign up for.

We can hope it's not for the rest of one's life but only until a better solution is found. For people with deadly allergies, a few years of injections might not be too big of a price, I think.

Yeah this is one of those perspective things. I’m on a once-a-month regimen of eyeball injections to stave off macular degeneration. I’d trade it in a heartbeat for allergy-reducing injection. But even my case feels “routine” now.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#64

Post by jlebar »

oaiey wrote: post #54
monero-xmr wrote: post #18

Earlier quoted context omitted.

It’s annoying to read “so and so new drug costs too much.” Creating new drugs is absurdly expensive. Most new drugs target small population groups, which is why treatments do not already exist - the low hanging fruit with large market potential gets targeted first. Just be happy a flag is planted in the ground. New drugs will be created from this that are different enough to avoid the patent, and new research will en…

While true, there is more money going in executive compensation / stock than into research. So there is plenty of space for lower prices. Plenty.

Citation needed?

Here's the 2023 report from Roche, which owns Genentech.

https://assets.roche.com/f/176343/x/0ef2047502/ar23-roche-ho...

Page 17 shows that R&D costs for pharma is 10-20x larger than equity-based compensation. That's all stock-based compensation, for execs and regular people. Your claim is that it's the opposite.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#65

Post by DinaCoder99 »

modeless wrote: post #46
DoreenMichele wrote: post #35

It's a 16 to 20 week course of treatment and reduces risk of anaphylaxis for accidental exposure to food allergens. There is at least one other drug that is used to treat peanut allergies, but this treats multiple food allergies. Given that anaphylaxis can be deadly and staff at food places can be sometimes less than reliable about food allergy concerns, I can see this being appealing to someone with severe food alle…

The study lasted 20 weeks, but I believe you have to continue the treatment indefinitely if you want the effects to continue. It's not a permanent fix, and a once or twice monthly injection for the rest of my life is not something I'd like to sign up for.

> It's not a permanent fix, and a once or twice monthly injection for the rest of my life is not something I'd like to sign up for.

Seems better than dying of anaphylaxis but what do I know.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#66

Post by duskwuff »

a_gnostic wrote: post #30
spondylosaurus wrote: post #21

Earlier quoted context omitted.

To be fair, Xolair isn't a new drug at all (it's been around for 20-ish years, I think?), this is just a new thing that it's approved for. I'm not sure why a generic hasn't hit the market yet, though. Maybe there's not enough demand to make it lucrative enough, unlike the golden child adalimumab...

What's the Mexican name? Asking for a Mexican friend.

Generic name for Xolair is omalizumab.

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#67

Post by cosmodisk »

yosito wrote: post #42
DoreenMichele wrote: post #35

It's a 16 to 20 week course of treatment and reduces risk of anaphylaxis for accidental exposure to food allergens. There is at least one other drug that is used to treat peanut allergies, but this treats multiple food allergies. Given that anaphylaxis can be deadly and staff at food places can be sometimes less than reliable about food allergy concerns, I can see this being appealing to someone with severe food alle…

> staff at food places can be sometimes less than reliable about food allergy concerns As someone with Celiac disease, who often eats at restaurants, this is a bit of an understatement. Even in restaurants where things are marked allergen free on the menu, it is often the case that staff will make mistakes. More often than not, staff aren't even informed about the basics of food, things like eggs and dairy being two…

Our daughter is allergic to a few things,nuts being one of them. When we ask for food information at restaurants, often staff have no clue. We had cases where they couldn't confirm for sure even after checking with the kitchen( we walked away).

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#68

Post by modeless »

DinaCoder99 wrote: post #65
modeless wrote: post #46

Earlier quoted context omitted.

The study lasted 20 weeks, but I believe you have to continue the treatment indefinitely if you want the effects to continue. It's not a permanent fix, and a once or twice monthly injection for the rest of my life is not something I'd like to sign up for.

> It's not a permanent fix, and a once or twice monthly injection for the rest of my life is not something I'd like to sign up for. Seems better than dying of anaphylaxis but what do I know.

The risk of dying from anaphylaxis is almost universally exaggerated. There is a lot of fearmongering about it, especially for parents.

The truth is, even for food allergic people, the risk of death is low compared to other causes. EpiPens are very effective. Also, anaphylaxis is a very temporary condition. If you do get anaphylaxis then after a very short recovery period there are zero long term effects to worry about.

It's questionable whether intensive and risky treatments are warranted in most cases (remember Xolair carries its own risk of anaphylaxis).

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#69

Post by spondylosaurus »

monero-xmr wrote: post #24
spondylosaurus wrote: post #21

Earlier quoted context omitted.

To be fair, Xolair isn't a new drug at all (it's been around for 20-ish years, I think?), this is just a new thing that it's approved for. I'm not sure why a generic hasn't hit the market yet, though. Maybe there's not enough demand to make it lucrative enough, unlike the golden child adalimumab...

I wasn’t aware of this, thanks for clarification. I will leave my comment as-is because it’s my take on the general “we need to ban price gouging on new drugs!” sentiment.

Ha, I certainly agree about the price gouging! I've stayed at jobs I hated just to keep my health insurance (and therefore my meds) :P

Re: FDA approves first medication to reduce allergic reactions to multiple foods

#70

Post by spondylosaurus »

kortex wrote: post #33
spondylosaurus wrote: post #21

Earlier quoted context omitted.

To be fair, Xolair isn't a new drug at all (it's been around for 20-ish years, I think?), this is just a new thing that it's approved for. I'm not sure why a generic hasn't hit the market yet, though. Maybe there's not enough demand to make it lucrative enough, unlike the golden child adalimumab...

IIRC, MABs aren't really a thing, because unlike small molecules, part of the approval is for the whole biological pipeline to produce the antibodies, from cell line to chromatography to formulation. When a small molecule goes off patent, you just have to prove to the FDA you can make that molecule to sufficient purity. That's not to say there are no generic MABs, it's that it is a far costlier process for the generi…

I have seen a lot of generics for TNF inhibitors MABs, but that might just be because there's soooo much demand for those drugs. (Humira was one of the most profitable drugs of all time, after all.) Right now I'm on an infliximab biosimilar!
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