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A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

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Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#61
post #57

Earlier quoted context omitted.

"with larger more complex molecules." What are "larger, more complex, molecules"? Without trolling, I think scent cuts off at a MW 330 or something.

But it's not as good with distinguishing complex organic molecules one from another, no? I.e. between various proteins of a similar size.

Mass spectrometry gives results that are a bit like the ingredient lists for food. Tells you precious little about the actual product.

Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#64
post #51

> But Joy's superpower is so unusual that researchers all over the world have started working with her and have discovered that she can identify several kinds of illnesses — tuberculosis, Alzheimer's disease, cancer and diabetes. The story for diagnosing Parkinson’s sounded plausible until this sentence. With Parkinson’s, you could imagine that she had some sort of sensitivity in her smell to a certain biomarker. Now…

Would it be so surprising if she just has an unusually adept sense of smell?

I think the surprising thing to a lot of people, even doctors, was the fact that a disease like Parkinson’s even had a “smell” in the first place. It sounds like now we understand a lot more about this as a result of these individuals ability to smell it!

Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#65
My father had Parkinsons. And was an engineer that used degreaser, i.e. trichloroethylene. And had 'the smell'. I think it's actually more common for people to detect this smell than perhaps is implied by these articles. I suppose the lady in question was just the first to notice and bring it to the attention of the medical community.

https://www.science.org/content/article/widely-used-chemical...

Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#66

> But Joy's superpower is so unusual that researchers all over the world have started working with her and have discovered that she can identify several kinds of illnesses — tuberculosis, Alzheimer's disease, cancer and diabetes. The story for diagnosing Parkinson’s sounded plausible until this sentence. With Parkinson’s, you could imagine that she had some sort of sensitivity in her smell to a certain biomarker. Now…

That might be just an imprecise formulation by the journalist. Smelling tuberculosis seems plausible to me, it is a disease of the lungs. General cancer probably no, but I have repeatedly read comments by oncologists that sarcoma, specifically, has a distinct smell.

My sister worked in urology and could smell bladder cancer

Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#67
post #59

People with the common cold smell like dying flowers about 2-3 days before any symptoms appear. It took me until my 30s to discover other people didn't know/realise/detect this. But since I've shared it with people as an interesting party trick type thing I've found many people who could smell onset of a cold. It's not surprising to me that people can smell so much more, as all of our senses differ from person to per…

How do you do this socially?

You're probably not sniffing random people to chat them up with "you'll have a cold in 3 days", right?

Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#68
post #59

People with the common cold smell like dying flowers about 2-3 days before any symptoms appear. It took me until my 30s to discover other people didn't know/realise/detect this. But since I've shared it with people as an interesting party trick type thing I've found many people who could smell onset of a cold. It's not surprising to me that people can smell so much more, as all of our senses differ from person to per…

How do you do this socially? You're probably not sniffing random people to chat them up with "you'll have a cold in 3 days", right?

Not random people, no, but it's a useful signal for "that person is probably contagious right now so I'll give them a wide berth".

I have got into the habit of telling people close to me, and it gives them a chance not to avoid getting a cold, but to mitigate the impact by treating the symptoms before they've really emerged.

Re: A woman who can smell Parkinson's is inspiring research into diagnosis (2020)

#70

Earlier quoted context omitted.

That might be just an imprecise formulation by the journalist. Smelling tuberculosis seems plausible to me, it is a disease of the lungs. General cancer probably no, but I have repeatedly read comments by oncologists that sarcoma, specifically, has a distinct smell.

Makes me realise there is no real way to notate a smell. How do people even get a handle on what a smell is, and how personal an experience is it.

This is a great observation! Indeed, most languages have very few words for smells.

- https://www.theatlantic.com/science/archive/2015/11/the-voca... - https://www.wired.com/2014/11/whats-up-with-that-smells-lang...

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