Not to be dismissive but it seems like a skill issue to me. I have the thread emoji muted, that does 90% of the work. I had to click “don’t show me this guy” ( not “don’t show me this topic”) on maybe half a dozen that slipped through, and then it seems like the algorithm got the message. Just curate better and the problem goes away.
This need to constantly curate is what made me leave Twitter years ago (well before Musk bought it). It's just too much work too little reward.