TL;DR: Windows Defender had a bug that made certain system calls expensive on CPU cycles when Defender's Real-time Protection feature is enabled. After discovery, Mozilla reported this issue to Microsoft. Microsoft is releasing a patch that should result in lower CPU usage when using Firefox on sites like YouTube (a ~75% CPU usage reduction was noted when browsing YouTube in Firefox with the fixed version of Defender…
It also has a bug(?) which makes method calls 100x slower in PowerShell 7: