Regarding acme, everyone comes in and goes "Yuck, you mean I can't type 'C-c M-x undoify'?" However, once you get used to it, it's actually rather nice. I have something like 30-40 files open in acme right now, and I find it far, far easier to manage open buffers than in Emacs. Arranging and re-arranging buffers (to use the emacs term, since it's familiar) is very convenient and helps me keep things organized.
It also has "mouse shortcuts" (chords) that tend to reward using the mouse more--meaning you don't need to switch from mouse to keyboard as often, because you can do cut, copy, paste, search, command execution, etc. all with a click of the mouse (and no hunting through menus, either).
It's hard to explain... you really have to use Acme, or even better, watch someone use it. http://www.youtube.com/watch?v=dopu3ZtdCsg seems to be a decent intro, although I haven't had time to watch the whole thing yet.