I've always found the framework we use to search for extraterrestrial life to be too based on our own experience. It could take countless forms, most of which we could never recognize or understand, and might be present everywhere without us knowing. I'm glad that more of the science community is pushing to broaden our horizons.
There is also this to consider: limits of our own imagination/ comprehension.
If we are like microbes swimming inside a droplet of water, we won't be able to imagine/ comprehend / detect beings of the scale of say flies.
Our mental abilities may also be limited in similar ways. I think that puts a limit on what we can perceive / detect / understand.