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Fentanyl vaccine tested in rats

uh.edu

61–70 of 378 posts

Re: Fentanyl vaccine tested in rats

#61

Earlier quoted context omitted.

No, it's a miracle painkiller used by doctors all over the world. Just like oxycontin it has a legitimate medical use.

Please don't do this, it's very tiring to discuss like this. He's obviously talking about illegal fentanyl use.

It takes effort to discuss things with people who don't already agree with you.

Re: Fentanyl vaccine tested in rats

#62
post #39

Earlier quoted context omitted.

And how do you propose we get all the users vaccinated with the fentanyl jab? Another round of mass vaccinations? Make all the kids in school do it? Forced vaccinations for anyone in jail or rehab? Honestly, all of those seem like bad ideas.

Didn't we already do it? Ban people from working if they don't take it, maybe take away any benefits too. Don't allow them to public places?

This is a frighteningly totalitarian comment.

Re: Fentanyl vaccine tested in rats

#63

Earlier quoted context omitted.

No, it's a miracle painkiller used by doctors all over the world. Just like oxycontin it has a legitimate medical use.

Please don't do this, it's very tiring to discuss like this. He's obviously talking about illegal fentanyl use.

I agree, it is very tiring when people suggest that medicine was invented and manufactured by the Chinese so that specifically Americans would abuse it. "Grey zone warfare".

This is a wild conspiracy theory. It's on par with the Chinese conspiracy theory that COVID was an American bioweapon.

Re: Fentanyl vaccine tested in rats

#64
> "a vaccinated person would still be able to be treated for pain relief with other opioids [such as morphine]"

Good to hear, but at its worst, my pain was only relieved by fentanyl (administered by a professional in a hospital). Noticeably better than Dilaudid (hydromorphone).

Is morphine a reliable replacement for fentanyl? Fentanyl is used quite often in palliative care because it lacks the side effects of morphine, is this correct?

Re: Fentanyl vaccine tested in rats

#65

Earlier quoted context omitted.

Please don't do this, it's very tiring to discuss like this. He's obviously talking about illegal fentanyl use.

I agree, it is very tiring when people suggest that medicine was invented and manufactured by the Chinese so that specifically Americans would abuse it. "Grey zone warfare". This is a wild conspiracy theory. It's on par with the Chinese conspiracy theory that COVID was an American bioweapon.

Really? I think a country like China could shutdown the export of Fentanyl precursor chemicals to bad actors almost overnight if they chose too. Im not suggesting the CCP is manufacturing it themselves but that they are happy to stand aside and do nothing. Not a conspiracy theory at all.

Re: Fentanyl vaccine tested in rats

#66
post #28

Earlier quoted context omitted.

Although fentanyl is used for anesthesia, especially for deep sedation, it is not the only option. From the article: “The anti-fentanyl antibodies were specific to fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. That means a vaccinated person would still be able to be treated for pain relief with other opioids,” said Haile So they could still use other opioids for anes…

https://www.reddit.com/r/science/comments/yvnr4n/comment/iwg... "So I’m an anesthesiologist. This vaccine would wreak havoc with surgery. Fentanyl is the go-to opioid for surgery. If you can’t use fentanyl then sufentanil can be used instead. Both are desirable because they have durations of under an hour which allows for surgical analgesia but still waking the patient after the procedure. The abstract here says the…

Of course fentanyl is the preferred opioid for a reason. Using other options could increase surgical risks. But that seems pretty insignificant for anyone with OUD given how likely they are to die from overdose vs. other causes.

Re: Fentanyl vaccine tested in rats

#67
post #53

Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…

>sell a new product to help solve the mess that one of their previous products created

That's gotta describe like 75% of US healthcare budget, right?

Red Dye #40, BPA, preservatives, emulsifiers, PFAS -> ADHD, Anxiety, Depression -> Adderall, Xanax, Prozac

Sugar, seed oils, preservatives, endocrine-disrupting chemicals in food, water & air -> Obesity, hypertension, diabetes -> Lipitor, Insulin

Alcohol, smoked/grilled meat, tobacco, microplastics, pesticide residues, air pollution from cars & factories -> cancer

Re: Fentanyl vaccine tested in rats

#68

Earlier quoted context omitted.

Isn't the whole point of doing it in rats that it's way more similar to humans than say Drosophila flies? Somewhat related: has the result from the Rat Park experiment been debunked or shown not to apply in humans? https://en.wikipedia.org/wiki/Rat_Park

The link you posted says that the original rat park researcher's own graduate student was unable to replicate the original experiment when he tried reducing the confounds. That seems like the most favorable possible situation for a replication to me. It also says that one confound was that morphine consumption wasn't measured in the same way between conditions in the original experiment. That seems pretty bad to me.…

Just saying, since neither humans nor rodents typically live in cages, maybe rodent experiments would be more predictive of human behavior if they weren't forced into living in small cages.

Re: Fentanyl vaccine tested in rats

#69
post #29

Earlier quoted context omitted.

Opioid overdoses are typically due how opioids effect the brain, so this would prevent fentanyl from contributing to and overdose.

Opioid overdoses are typically due to overestimation of one's tolerance or underestimation of the strength of the drug being taken, and what you are responding to is a way that a weakened fentanyl effect could lead to that.

You could still OD, but it would not be a fentanyl OD, because the fentanyl in the drug would not be able to interact with the brain. If you took this vaccine, it seems like you would be just as likely to OD from heroin as you would from fentanyl+heroin.
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