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And is that nonsense or is there evidence that backs it up?
I am sure fasting proponents promise way too many things, but the underlying cell cleanup mechanism [0] is very real and received the Nobel Prize in 2016 [1] [0] https://en.wikipedia.org/wiki/Autophagy [1] https://pubmed.ncbi.nlm.nih.gov/27912049/
Proponents of fasting will love this, since the idea is that not eating for a while will cause the body to scavenge for this old / damaged cell material.
But here we want cells to eat themselves, not damaged organelles. I believe nuclear DNA isn't among the things cleaned up by autophagy.
The ProNukes have gone too far this time.
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I am sure fasting proponents promise way too many things, but the underlying cell cleanup mechanism [0] is very real and received the Nobel Prize in 2016 [1] [0] https://en.wikipedia.org/wiki/Autophagy [1] https://pubmed.ncbi.nlm.nih.gov/27912049/
The wiki page does not mention fasting.
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Diesel is a scandal many orders of magnitude bigger than asbestos and smoking, and we'll look back on it with that reverence. That in the UK most diesel drivers remove their particulate filters to increase fuel efficiency (meaning that essentially every white van on the road is rolling coal like a Texan), makes it all the worse. It's not even the lung damage, the brain damage that's been caused (there's ongoing resea…
> in the UK most diesel drivers remove their particulate filters Are you sure about that? Sound quite crazy to me. > to increase fuel efficiency How much would that save? > Diesel is a scandal Yes, what the car manufacturers did is horrible and it is also horrible that governments did not find it out or enforce it. An even bigger scandal is that UK diesel drivers remove their particulate filters to save a few bucks.…
That all said, testing wasn’t mandatory for most of Covid and emissions aren’t really tested properly even though they were supposed to be years ago (emissions tests won’t detect removed particulate filters if you don’t accelerate during the test, so the garage that just took a bribe to remove your filter can choose not to do that and wave you on through).
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I am sure fasting proponents promise way too many things, but the underlying cell cleanup mechanism [0] is very real and received the Nobel Prize in 2016 [1] [0] https://en.wikipedia.org/wiki/Autophagy [1] https://pubmed.ncbi.nlm.nih.gov/27912049/
The wiki page does not mention fasting.
> We conclude that both fasting and CR have a role in the upregulation of autophagy, the evidence overwhelmingly suggesting that autophagy is induced in a wide variety of tissues and organs in response to food deprivation
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> in the UK most diesel drivers remove their particulate filters Are you sure about that? Sound quite crazy to me. > to increase fuel efficiency How much would that save? > Diesel is a scandal Yes, what the car manufacturers did is horrible and it is also horrible that governments did not find it out or enforce it. An even bigger scandal is that UK diesel drivers remove their particulate filters to save a few bucks.…
Also cost. It's about EUR200 to (illegally) remove it, and quite a bit more to change it every 100k or so (numbers are not exact, been a while since I researched).
It can cost up to £2k to replace the filter if it fails on an expensive model, which happens quite regularly for less reliable models.
> 99% of people in the world live in places where air pollution exceeds the WHO guidelines Wow. I knew cities are polluted but this is extreme. In 50 years we might look at pollution as we look at smoking now, a terrible self-inflicted wound on civilization that took way too long to acknowledge and fix.
This is why BEV adoption should result in a very large drop in cancer and other health problems. EV drivers have told me after a bit of ownership, they see ICE cars as thoroughly filthy, loud, dirty, inefficient, and almost rude. Our addiction to being able to drive places with but a mere tap of a gas pedal has blinded us to the devil's bargain of the ICE. I honestly think that a great deal of the instinctive hatred…
https://www.sciencedirect.com/science/article/abs/pii/S13522...
Don’t get me wrong, they are much better than ICEs in terms of total emissions, but not for this particular issue.
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Spermidine does this as well. https://www.tandfonline.com/doi/full/10.1080/15548627.2018.1... If you want to know how to increase it ask me how.
> If you want to know how to increase it ask me how. how?
But we cannot stop here since this might just mean that you spin the urea cycle around and around. What we need to do is stimulate Orniothine Decarboxylase (ODC) to pull the ornithine out of the urea cycle to the polymaine pathway. ODC need B6 as a cofactor to increase activity so taking B6 or eating foods high in B6 will do well here.
Not that we have the ornithine going where it need we need to make sure we can turn it into spermidine by making sure we have enough of the coenzymes for those enzymes. The coenzyme here is SAMe.
And that's it. But be careful, because if you have messed up genetics like me you already make enough spermidine and it will cause great mental turmoil, even suicidal thoughts.
Here is the pathway: https://www.science.org/cms/10.1126/science.aan2788/asset/5e...
On mental illness and spermidine: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293545/
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Don't forget the fraud of the whole Dieselgate scandal. We were all getting excess NO2 pumped out of diesel engines. Effectively shortening all our lifespans.
I'm not defending the lying here, but ultimately the dieselgate scandal was triggered by too aggressive of regulations that exceeded the possible tech. Most companies decided to just pull diesel cars from the US market, and it turns out that all of the ones that stayed were tricking the tests in one way or another. The diesels of that era that were having to trick the test, were also orders of magnitude cleaner than…
> The Volkswagen XL1 plug-in diesel-electric hybrid was available only in Europe and its 5.5 kWh lithium-ion battery delivered an all-electric range of 50 km (31 mi)
