Earlier quoted context omitted.
It is pressurizing on output due to the flow through the device, the same thing causes some underpressure when breathing in. But I doubt it is enough to draw a vacuum strong enough to break adhesion. Still, better safe than sorry, it would be good to read the instruction manual of a professional unit to see what kind of failure modes they have listed there.
I read a lot of stuff back in 2020 because I was going to be coding up controls for an emergency ventilator... you would not believe just how little pressure difference it takes to permanently ruin your lungs... less than 1 PSI if I recall correctly.
Standard CPAP machines max out at just over 0.25psi, and even ventilators usually max out about 0.4-0.5psi.