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Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

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Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#61

Post by dpark »

ouid wrote: post #52
nick__m wrote: post #47

Earlier quoted context omitted.

A placebo is frequently better than nothing and sometimes better than the real thing. I can even work if you know that it's a placebo ! Also placebo are getting stronger https://drdavidhamilton.com/the-placebo-effect-is-getting-st... ;)

Mechanistically, placebo can only work on psychosomatic symptoms. There isn't any magic going on. If the problem is in your head, then thoughts can maybe help.

Your head largely controls the rest of your body. If you take a placebo that you expect to make you angry, your levels of adrenaline will likely rise. There are all sorts of measurable, physiological changes that can be induced by placebo.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#62

Post by merpnderp »

wantsanagent wrote: post #44

This is a big hammer. Please note this section: "A proton pump inhibitor (PPI) pantoprazole 40 mg/day was also prescribed for gastric protection. Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole." Induced hemophilia is no joke.

Do people really get holes in their stomach often enough that this regiment would cause them to bleed to death?

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#63

Post by runnerup »

JPKab wrote: post #19
runnerup wrote: post #8

Earlier quoted context omitted.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

I have a recommendation for you: You need to exercise. You are in your mid-thirties now. It's a big problem if you don't. But you have bad air quality where you live. I've dealt with this myself in the past. A relatively inexpensive solution that I recommend for anyone in areas with poor air quality is to build your own filter fans. Get a standard box fan, get a furnace filter that has HEPA ratings, duct tape the fur…

I appreciate this. I used to row competitively through high school and college, so I do consider myself an "athlete" as an identity, but non-practicing. I recently lost 30 lbs (6'0" from 200lbs to 170 lbs) over the past year through diet, but need to exercise.

Your advice for air filters is good general advice, IMO. I have a 700 sqft apartment with:

1x Honeywell HPA300 (rated for 465 sqft)

6x Coway AP-1512HH (each rated for 361 sqft)

1x Honeywell HPA100 (rated for 155 sqft)

I also have a Honeywell FPR 10 filter on the HVAC air return. So, over 2800 sqft of CADR-rated filtering for a 700 sqft apartment. Activated carbon pre-filters are changed every 2 weeks and the HEPA filter is changed once a month. We spend about $400/mo on filters, on top of $1,100/month rent.

Unfortunately, HEPA filtration does little for the type of air contamination that we're dealing with. Ethylene oxide is more like a "VOC" than a "PM2.5". The activated carbon filters help a bit, but are "used up" very quickly (1-2 days IME). The HEPA filters do very little/nothing for VOC contamination as far as we can tell.

Indeed, it is time to move away. I am in one of the most heavily-affected featured areas in this article[0]. However, my wife and I work in the chemicals industry, so we have personal experience identifying most of the compounds by smell and have unusual awareness of their effects vs. most of the nearby citizens.

0: https://www.propublica.org/article/toxmap-poison-in-the-air

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#64

Post by merpnderp »

mkarliner wrote: post #48

So 24 patients reported relief of symtoms. It would occur to me that a placebo effect could account for this. A study with a control group would hold greater validity in my mind. This seems purely anecdoctal despite academic styling.

Placebo effect accounts for changes in their blood markers for micro clots? I'm a big believer in the power of the mind, but this seems a stretch.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#65

Post by nradov »

imnotreallynew wrote: post #58

It was my understanding that the existence of “long covid” is still debated as there hasn’t been any real evidence for it other than patient anecdotes.

Most any serious viral infection can potentially cause post-viral fatigue syndrome. We've known that for decades and COVID-19 is nothing special in that regard.

https://pubmed.ncbi.nlm.nih.gov/3063394/

But many cases of "long covid" appear to be psychosomatic.

https://jamanetwork.com/journals/jamainternalmedicine/fullar...

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#66

Post by runnerup »

sva_ wrote: post #42
runnerup wrote: post #8

Earlier quoted context omitted.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

Are you sure it's caused by COVID, or perhaps ever since you were sick you were exercising less? I had similar symptoms to what you describe after just not being very active for quite a while, but it resolved after I did regular cardio (cycling) for a while and ate better.

I noted:

> I've never had COVID.I did get the mRNA vaccines + booster.

Regardless of root cause, probably just need to exercise more. See a doctor for good measure. Could be age/underlying condition, but exercise improves most of these things.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#68

Post by runnerup »

kingsloi wrote: post #17
runnerup wrote: post #8

Earlier quoted context omitted.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

I had similar symptoms in January 2019, I went to Urgent Care and then the ER because of heart arrhythmia, I felt sick, but no major fever. I put it down to anxiety (never suffered with before), but part of me wonders if it was COVID. Out of curiosity, where do you live? I too live next to a bunch of chemical/steel plants and have been tracking air quality, weather, traffic, etc. https://millerbeach.community in Gary…

Propublica has some excellent research published lately (it's an entire series of articles based on one primary analysis): https://www.propublica.org/article/toxmap-poison-in-the-air

It's based on somewhat-voluntarily reported data, rather than measured air samples. Mainly because we don't have effective air monitoring stations in anywhere near enough density to any kind of useful data science.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#69

Post by merpnderp »

kybernetyk wrote: post #28
JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

>I think I’m going to start taking aspirin. Hmm, this is probably hardcore anecdata and off topic but a friend of mine who got Corona pretty bad (but not hospital bad) said that once he took Aspirin his symptoms weren't that bad anymore.

I mean everyone should consult their doctor before doing something like this, but it seems reasonable that a disease which damages the body through blood clots would be alleviated by a drug which thins the blood.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#70

Post by nradov »

runnerup wrote: post #8
nicoburns wrote: post #4

Huh. This is interesting. I also have some fatigue, but my most obvious long-covid symptom is heart pain/strain which is aggravated by either an elevated heart rate or dehydration. I'm no expert, but intuitively this would seem to provide a good explanation of those symptoms.

I'm hopeful that research into whatever "long covid" syndrome is/isn't leads to excellent new medical knowledge that applies to much more than just COVID edge-cases. I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster. Since that fever, my heart…

Any one of us could have had an asymptomatic SARS-CoV-2 infection without knowing it. But there are myriad different medical conditions that can cause arythmia.
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