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Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

fiercebiotech.com

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Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#61

Post by sgmoore »

willcipriano wrote: post #14
tempdiabetic wrote: post #6

Earlier quoted context omitted.

The Dexcom G6 is the best CGM on the market, but its sensor filtering (Kalman or particle?) has smoothness and/or continuity priors that cause persistent inaccuracies. I observe these persistent inaccurate states on the fifth or sixth day using a sensor. Calibration doesn't help. The reading goes wrong and stays wrong. It probably happens to you, too, but anyone who doesn't test with a glucometer will likely not noti…

> 16x daily finger stick blood testing Is that typical for people with your condition? Once an hour while you are awake? I never knew people had to do it that often.

I think the usual recommendation is before meals, two hours after meals and before going to bed. So that was 7 times a day for me. The big problem with testing more times is that you are literally damaging your fingers and hoping that they heal before you need to use that area on your finger again. For me this didn't always happen and is one of the reasons I love my FreeStyle Libre.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#62

Post by tpoacher »

pacman2 wrote: post #48

I find some of the this vague in this announcement. Non invasive BGM is the "holy grail" in this field. Tons of companies have failed after big investments. Some scammers are out there they claim since decades they solved the problem. I would be curious about peer reviewed publications of their technology. A friend of mine is working on this too. Close to market. He is the only one that regularly published peer revie…

I have a counter-story.

When I started my Phd in 2011, one professor, an absolute top player in the field and prof in a top tier university, revealed that he had patented a fully functional prototype a few years back, which allowed similar cheap non-stick measurement of glucose (i think this was on a principle similar to pulse oximetry rather than RF).

The patent was swiftly bought by a large pharmaceutical company and "buried", in order to protect sales of blood-sticks; by far the main source of profit in diabetic devices (his words).

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#63

Post by criddell »

tpoacher wrote: post #62
pacman2 wrote: post #48

I find some of the this vague in this announcement. Non invasive BGM is the "holy grail" in this field. Tons of companies have failed after big investments. Some scammers are out there they claim since decades they solved the problem. I would be curious about peer reviewed publications of their technology. A friend of mine is working on this too. Close to market. He is the only one that regularly published peer revie…

I have a counter-story. When I started my Phd in 2011, one professor, an absolute top player in the field and prof in a top tier university, revealed that he had patented a fully functional prototype a few years back, which allowed similar cheap non-stick measurement of glucose (i think this was on a principle similar to pulse oximetry rather than RF). The patent was swiftly bought by a large pharmaceutical company a…

How do you bury a patent? They are all published, aren't they?

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#64

Post by specialist »

DougWebb wrote: post #37
LegitShady wrote: post #34

Earlier quoted context omitted.

so what foods did you cut out, and what foods do you regularly eat?

Everybody's body responds differently, so you have to experiment to see what works for you. The CGM has been a great tool for that. I also use a Keto-Mojo for blood glucose and ketone testing now and then. What's worked for me is a diet of eggs, cheese, bacon, chicken, ground beef, ground pork, roast beef, turkey, pepperoni, kale, cabbage, Brussels sprouts, coffee, seltzer, bone broth, half & half, heavy cream, rebel…

I did something similar for a while. Loved it. Great results.

How's your cholesterol, risk for heart disease, etc?

Having high LDL, I switched to a high fiber diet. My LDL hasn't budge.

So now I'm pondering what's next.

I have almost zero knowledge, opinions, ideas about what's best, for me or anyone else. The stuff I've read about cholesterol just confuses me.

One of the few things I did learn (about myself) is that calorie restriction works great. After a few days I barely notice. But adherence is very difficult when I'm in pain.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#65

Post by inetsee »

guywhocodes wrote: post #58
inetsee wrote: post #44

Earlier quoted context omitted.

I use a Freestyle Libre sensor and I like it better than finger sticks. When I was doing finger sticks I was averaging 4 tests a day; before each meal and at bedtime. With the Freestyle Libre I'm checking my glucose an average of 20 times a day. But the Freestyle Libre sensors are quite expensive. I have insurance so my out of pocket expenses are very low, but my provider bills $1074 for 2 sensors, which last for 4 w…

Your provider is being ripped off, I'm pretty sure my doctor is not selling them subsidized and I'm paying roughly US$62 each. I still find it quite expensive but it's acceptable with my income and taxation where I live.

The provider bills for $1074, but their actual reimbursement is only $208 for 2 sensors.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#66

Post by kemiller2002 »

criddell wrote: post #63
tpoacher wrote: post #62

Earlier quoted context omitted.

I have a counter-story. When I started my Phd in 2011, one professor, an absolute top player in the field and prof in a top tier university, revealed that he had patented a fully functional prototype a few years back, which allowed similar cheap non-stick measurement of glucose (i think this was on a principle similar to pulse oximetry rather than RF). The patent was swiftly bought by a large pharmaceutical company a…

How do you bury a patent? They are all published, aren't they?

When he says bury what he means is that no one can use it to build something. The company just holds it to prevent everyone else from using the idea.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#67

Post by GiorgioG »

kemiller2002 wrote: post #66
criddell wrote: post #63

Earlier quoted context omitted.

How do you bury a patent? They are all published, aren't they?

When he says bury what he means is that no one can use it to build something. The company just holds it to prevent everyone else from using the idea.

Sigh. Patents should really be use-it-or-lose-it.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#68

Post by GiorgioG »

rrrrrrrrrrrryan wrote: post #42
idealmedtech wrote: post #22

Earlier quoted context omitted.

Hi, this is actually my field of expertise! IdealMedTech is a clinical glucose control startup targeting inpatient glucose control. Having an MARD (mean absolute relative difference, or in math terms, E[|g-r|/r], g is measured glucose, r is reference glucose) of below 15% is actually considered very good for glucose monitoring. We did a study that involved modelling different levels of sensor error, and you actually…

> Most sensors on the market that are considered best in class (eg Dexcom G6) have guaranteed MARD Disclaimer: I work for Dexcom. A few times every year, there's a ton of hype about some new noninvasive device, and the newbies get a bit worried, but the old timers just shrug it off. We (humanity) will literally be able to regrow new pancreases with stem cells before we have accurate noninvasive blood glucose devices.…

Thank you for your work. My 9 year old son has worn a Dexcom for the past 3 years (Medtronic prior to that) and it's a godsend to be able to pair it with Sugarmate.io so we get phone calls in the middle of the night if his BG goes low.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#69

Post by tempdiabetic »

beardface wrote: post #59
KMnO4 wrote: post #30

Earlier quoted context omitted.

Anecdotal, but a Keto diet has completely flatlined my BG — in a very good way. I’m talking about being in the range of 4.8 to 5.8 for weeks on end. My endocrinologist thinks I’m a wizard and has never seen anyone with 100% in range. I also love that I never have to bolus with food. It’s the closest I can get to pretending I’m not a T1D. I just eat. If I’m full, I stop and don’t have to worry that I accidentally took…

> To reiterate, I take zero boluses when I’m on the keto diet. I'm very surprised by this and would love to hear what you eat while doing keto. I'm T1 but still have to bolus when doing keto, even when doing zero carb and fasting for 18+ hours a day. I only need between 1 and 3 units but there's rarely an occasion when I don't need to bolus at all. > Doctors are against it because they’re dealing with ketoacidosis on…

The brain uses ketones as fuel, so you will find that hypoglycemia is easily tolerated.

In ketosis, your brain will have plenty of fuel, even if your blood glucose drops too low.

Re: Know Labs unveils glucose monitor that swaps fingersticks for RF sensors

#70

Post by tempdiabetic »

idealmedtech wrote: post #23
tempdiabetic wrote: post #6

Earlier quoted context omitted.

The Dexcom G6 is the best CGM on the market, but its sensor filtering (Kalman or particle?) has smoothness and/or continuity priors that cause persistent inaccuracies. I observe these persistent inaccurate states on the fifth or sixth day using a sensor. Calibration doesn't help. The reading goes wrong and stays wrong. It probably happens to you, too, but anyone who doesn't test with a glucometer will likely not noti…

I've done accuracy studies of the G6 for a submission to the FDA, and while it's true they do filter out spikes, they're never more than 5mg/dL off from the measured value (which itself is usually within 10% of the real value). Interstitial lags are closer to 5 minutes when you're not experiencing severe perfusion issues, which is more than close enough for making dosing decision, especially considering subcutaneous…

Any diabetic can confirm for themselves my claim about the Dexcom G6's unacceptable persistent error states.

Simply compare the CGM with your glucometer (testing 8x per day, for example), and watch the CGM go wrong (and stay wrong) on day 5 or 6 of using the sensor.

I wish what you said was true. I would love to have a CGM that works better than a glucometer, but they don't exist yet. In particular, the Dexcom G6 is inaccurate in a harmful way.

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