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Why aren't the oldest living people getting any older?

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Re: Why aren't the oldest living people getting any older?

#61
The submitted article reminds me of a science fiction story I read as a child, "Hunting Lodge" by Randall Garrett, in the anthology Men and Machines edited by Robert Silverberg.

http://books.google.com/books?id=3PSTqQrrzjEC&pg=PA141&#...

The premise of the story is that an effective life extension treatment has been found, and it is so expensive that only the politically powerful can have access to it. The protagonist (and first-person narrator) of the story is an assassin whose job is to murder the immortal oligarchs who rule a future United States--it is pretty apparent that the target of his assassination plot is J. Edgar Hoover in a far-off future. That has always caused me to pause and think about whether I would really like society to discover an effective longevity treatment. Are you sure that people who are as high on the social power and influence scale as HN readers will have access to the treatment?

Re: Why aren't the oldest living people getting any older?

#62

I am unable to find a citation for this but I recall having read that Scientists had started to notice a pattern - The life span of a mammal is typically a function of the age of maturity. The function was a factor of 6. In humans age of maturity is approximately 20. So it is believed that the maximum lifespan is about 20*6 =120 years for humans.

This paper http://www.sciencedirect.com/science/article/pii/05315565939... seems to contradict that claim of a simple ratio between life variables.

Abstract:

A regression analysis was made of age at first reproduction in female mammals, as a function of body weight, using the data of Wootton. Data on maximal life span, also expressed as a function of body weight, were used to calculate “adult” life span, wherever possible, by subtracting the cognate value for age at first reproduction. Then a regression analysis of adult life span as a function of age at first reproduction was made. In both cases global regression lines (i.e., for whole data sets) were computed by standard least squares and by a robust method, as well as local regression lines for subgroups classified by taxonomic and ecological criteria. The slopes of the various regression lines were found to vary widely as a function of the method of classification. This result argues against the notion that the ratio of life history variables is a constant, or that one life history variable is likely to be a simple function of another. The results for bats are anomalous, in that age at first reproduction appears to be independent of body weight (over about two orders of magnitude). It is concluded that a full understanding of life history variables, such as maximal life span and age at maturity, is likely to depend on combined physiological, ecological, and evolutionary insights. Keywords: maximal life span; age at maturity; regression analysis; mammals

Re: Why aren't the oldest living people getting any older?

#63
post #32
post #21

It's important to make a distinction medically between pushing as many as people as possible towards the high-age end of that curve on one hand and scaling the entire X axis on the other. The first one is what we're currently doing with modern medicine, and it boils down to debugging the most common causes of premature death. The second one is completely separate from this and way harder to tackle because it involves…

We now know that human biochemistry is the result of an evolutionary process which when faced with a problem consistently comes up with the worst possible solution that is still workable. It's 3 billion years worth of crufty spaghetti code, literally. As someone educated in theoretical biology and learning theory, I object to this kind of characterization of the evolutionary process. There is no evidence for a superi…

There is no evidence for a superior magical learning algorithm that would have done better-- see the no free lunch theorem.

There's plenty of evidence that evolution is extremely inefficient. Due to its very nature it can't look forward, it can only hill-climb. Since evolution can't re-architect things, it gets stuck in local maxima all the time.

We can be reasonably sure of evolution's inefficiencies after looking at some some examples. Problems like the laryngeal nerve and backwards vertebrate retina are commonly brought up in these sorts of debates, but they forget that evolution doesn't even look at the vast majority of solution-space. It limits itself to squishy things in the discipline of biology. For example, neurons run at 10-200Hz and conduct signals at 0.000001c. Other substrates like silicon and diamond are much faster.

A human visual cortex has billions of neurons doing complicated procedures (edge-detection, FFTs, motion-detection, etc). But only a tiny fraction of humans can multiply two 4-digit numbers without the aid of pen and paper. Had the human brain been designed by a human, every programmer in the world would scream, "Why didn't you give us an API you idiot?!"

Of course, we'd also complain about the brain's lack of 4G, since evolution never invented a radio.

Re: Why aren't the oldest living people getting any older?

#65

I am unable to find a citation for this but I recall having read that Scientists had started to notice a pattern - The life span of a mammal is typically a function of the age of maturity. The function was a factor of 6. In humans age of maturity is approximately 20. So it is believed that the maximum lifespan is about 20*6 =120 years for humans.

This paper http://www.sciencedirect.com/science/article/pii/05315565939... seems to contradict that claim of a simple ratio between life variables. Abstract: A regression analysis was made of age at first reproduction in female mammals, as a function of body weight, using the data of Wootton. Data on maximal life span, also expressed as a function of body weight, were used to calculate “adult” life span, wherever pos…

Thank you for the link - this is good to know.

Re: Why aren't the oldest living people getting any older?

#66
post #21

It's important to make a distinction medically between pushing as many as people as possible towards the high-age end of that curve on one hand and scaling the entire X axis on the other. The first one is what we're currently doing with modern medicine, and it boils down to debugging the most common causes of premature death. The second one is completely separate from this and way harder to tackle because it involves…

It's important to make a distinction medically between pushing as many as people as possible towards the high-age end of that curve on one hand and scaling the entire X axis on the other.

This is a great synopsis of the situation. There is little research going into actually extending the human lifespan. It's fascinating to hear people like Aubrey de Grey describe some of that research (http://en.wikipedia.org/wiki/Aubrey_de_Grey).

Re: Why aren't the oldest living people getting any older?

#67
post #55

Earlier quoted context omitted.

Can you think of anything that might be informing that hunch?

Well, nicotine is an anorectic (reduces appetite), and calorie restriction is the most proven life-extension technique known (in rats), so there is the idea that nicotine --> unintentional calorie restriction --> potentially longer lifespan. Nicotine is a lot easier on the body than other anorectics, which sounds like a weird claim but "other anorectics" means nasty things like methamphetamine and fenfluramine; nicot…

Anorectic; yeah, no kidding... I smoked for 13 years and am 6"1' and weighed in at 160 lbs. I stopped at 28 and shot to 205 in less than a year.

Re: Why aren't the oldest living people getting any older?

#68

Earlier quoted context omitted.

The waters are figurative; they basically represent chaotic universal essence which God separates and shapes. If Plato wrote Genesis he would have said aether. We would probably refer to a singularity or strings or something else we think everything is made of.

Or the waters are literal; and it represents that the Bible was written by a pre-modern people with nothing more than their imagination to guide them. I think Plato would have been embarrassed to be caught anywhere near Genesis.

I assume you are saying that we should just believe whatever we like about old documents. I don't think that is a good idea. It's better to determine what the writers meant by conducting a careful linguistic study based on other texts, archeology and historical accounts written by people who seem to have had access to evidence that is now lost.

"Plato meets Moses" speculation is just fun, though. Since Plato was a monotheist I think he would have found enough common ground to debate with Moses. I expect the two would have disagreed on whether the forms were in God or residing elsewhere. The creation account in Genesis and in Timaeus are both geocentric accounts of an initially perfect creation, etc. They also would have agreed that the homogenous mixture of the elements was the same as the homogenous "formless and void," "surface of the waters" etc., but they definitely would have disagreed about the demiurge vs God/Satan, and also disagreed about quite a lot of what happened after creation. That's my speculation, anyway.

Re: Why aren't the oldest living people getting any older?

#69
post #21

It's important to make a distinction medically between pushing as many as people as possible towards the high-age end of that curve on one hand and scaling the entire X axis on the other. The first one is what we're currently doing with modern medicine, and it boils down to debugging the most common causes of premature death. The second one is completely separate from this and way harder to tackle because it involves…

Here is one problem with life extension that I haven't seen mentioned - can we just assume that people who grew up in vastly different time periods will just be be able to coexist comfortably?

To give an obvious contemporary example - gay marriage is a lot more controversial among older American voters than younger voters.

Now multiply that times a thousand - what if people who grew up in the time of Christ were still a significant part of the voting population? We can't just assume they'll all become hip techno-libertarian atheists/extropians just because they managed to live long enough. My guess is that they'd have a strong attachment to the values and way of life they grew up with - thus creating potentially bitter conflicts among the different cohorts which might make contemporary domestic politics seem downright friendly.

So while its cool to imagine living indefinitely - it seems to be in many ways healthier for society to have a continuous "purge", to constantly start fresh with new minds that have less baggage from the past.

Also on a personal note - if society in 2,000 years is radically transformed into something I find really bewildering and bizarre - do I really want to be around for that? Of course I would gamely try and adapt, but it might be better for everyone to just leave that future world for people who grew up with it and who find it natural.

Still, I am not any kind of Luddite - if life extension and mind uploading etc. is perfected I won't oppose it - I'll just have a lot of misgivings as will a lot of other people.

Joe Haldeman's "Forever War" has some good exploration of the nature of "Future Shock": http://en.wikipedia.org/wiki/The_Forever_War

Actually, now that I think about it, if this whole scenario actually happens the best thing might be to maintain separate societies for people born in different time periods, which can communicate and interact but which operate relatively independently.(e.g. Being gay might be illegal in the 1000 CE society but being straight could be illegal in the 3000 CE area!) That might be the only way to keep some relative peace.

Re: Why aren't the oldest living people getting any older?

#70
post #21

It's important to make a distinction medically between pushing as many as people as possible towards the high-age end of that curve on one hand and scaling the entire X axis on the other. The first one is what we're currently doing with modern medicine, and it boils down to debugging the most common causes of premature death. The second one is completely separate from this and way harder to tackle because it involves…

I'd say there's little value in trying to fix what's broken to the core. Research should focus on ways to extract one's consciousness from the body and place it in an artificially designed shell (a Ghost in the Shell, one might say).

I know little about either side of the argument, but it seems to me that we'd have more chance of success (however small) extending the life of a complex body that supports a mysteriously complex brain and intellect, than to ever hope that we can extract consciousness at all, much less have it operate anywhere near its current level without its supporting body.

How much consciousness is in the physical body, and not just the brain but the rest of the body? Do we really know?

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