I have switched to pure HTML/CSS/Javascript for frontend. And I am very happy with it. I sometimes use external libraries. For example handlebars if I want to template something clientside. But no more frameworks. I think pure Javascript is plenty enough these days. For those who can't live without a framework: What would you miss?
Well, my favourite of choice is Elm, and it's correctness guarantees are really a huge deal to me. Whenever I have to do react or even just vanilla js for work, unless it's really miniscule I will nearly always run into runtime errors because I just forget to check something for null or do something stupid like not awaiting a promise (and that's before any other developers get involved). Typescript helps out a certain extent but I find it isn't nearly prescriptive enough. It's not like I'll ever convince my company to adopt Elm though (and believe me, I tried), so c'est la vie.
Although I suppose these might be considered different languages rather than just a framework, which is where the benefit comes from? It might be just that I'm not very good with dealing with JS as a language rather than needing a framework specifically.