61–70 of 86 posts
I like that comment from a few days ago https://news.ycombinator.com/item?id=16675412 > Go look at the studies showing resistance training to be pretty effective in seniors before getting excited about NAD+ boosters. The resistance training is probably cheaper and better. One still has studies such as the one showing that dietary nicotinamide doesn't do a great deal in mice [3] - like sirtuin manipulations, it helps…
Earlier quoted context omitted.
Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/
I've been taking Niagen for a couple of months, and I can say that for me it feels much better than niacin or niacinamide. I don't know why (perhaps I have some niacin metabolism problem, or the niacin interferes with some other impaired process such as the methylation cycle). Also there seems to be some synergy between Niagen and resveratrol and pterostilbene that I can clearly notice. Foods that work well with Niag…
Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.
Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/
https://www.quora.com/What-is-the-difference-between-nicotin...
"Among "salvageable precursors" (i.e., Na, Nam, NR), a lot of focus is on NR these days because apparently it activates the "anti-aging" sirtuin genes at high concentrations too compared to Na and Nam which only activate those "longevity" genes only at small concentrations and deactivate them at higher concentrations."
https://www.ncbi.nlm.nih.gov/pubmed/18429699
"Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis"
I think calorie restriction is a more interesting idea, because it forces you to think about eating high-nutrient foods. The first things I did were to eliminate sugars and other processed ingredients, including all flours. Continuing to eat junk and assuming that pills and supplements will compensate for that is probably not a good idea.
From the article: > From a public health perspective [restricting calories] would be impractical for many and dangerous for some. Regardless of what's the most optimal solution it's very helpful to have the option when this isn't an easy/practical option. And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my…
I don't get the time and monetary cost either. You can precook your meals for a whole week on Sunday night, as long as you don't mind a little repetition.
Earlier quoted context omitted.
Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/
Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour. https://niacinreviews.com/niacin-max-flush/
Definitely want to use the non flushing version.
Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.
Earlier quoted context omitted.
As far as I know it's fairly hard to synthesize, and isn't produced in large quantities yet.
Smoking cigarettes would do it. Nicotine + Oxygen right? Who knew the movie Sleeper had it right, keto diet and tabacco. https://www.youtube.com/watch?v=D2fYguIX17Q
I like that comment from a few days ago https://news.ycombinator.com/item?id=16675412 > Go look at the studies showing resistance training to be pretty effective in seniors before getting excited about NAD+ boosters. The resistance training is probably cheaper and better. One still has studies such as the one showing that dietary nicotinamide doesn't do a great deal in mice [3] - like sirtuin manipulations, it helps…
I'd take 5 extra QALYs any day.