Earlier quoted context omitted.
Military?
Yes (and contractors, etc.)
I remember reading in a Tom Clancy book once that it's called "Light Fighter Candy".
Ibuprofen alters human testicular physiology including testosterone production
61–67 of 67 posts
Re: Ibuprofen alters human testicular physiology including testosterone production
#62Earlier quoted context omitted.
Military?
Collegiate and professional athletes easily would do this. (I've personally done it, hell.) Construction workers, manual laborers, etc.
True.
A lot of people I know that powerlift do 4 x 800mg for 5 days or so. I think the thinking is to give the injury a "blast" of ibuprofen to bring the swelling down fast, rather than a lower dose for a longer period.
Re: Ibuprofen alters human testicular physiology including testosterone production
#63Earlier quoted context omitted.
Six weeks isn't a long time if you've got a herniated disc.
Correct, hence if you need pain control for longer than 6w there might be other options
I know that certain herbal cookies work vastly better than ibuprofen, even a day after intake, but they're not prescribed very liberally around here.
Re: Ibuprofen alters human testicular physiology including testosterone production
#64This isn't really huge news, technically speaking. Any anti-inflammatory drug will have negative net impact on your body function. For a while we know now that NSAIDs alter ROS levels in response to injury and in fact any normal process. NSAIDs also have negative impact on training adaptation or cell death due to overexpression of ROS. So no - taking overabundant levels of oral NSAIDs isn't going to be good for you a…
The energy drink makers have been trying to defend the use of taurine in their ingredients for a long time. This looks like a golden opportunity for them....
Re: Ibuprofen alters human testicular physiology including testosterone production
#65This was discussed ~3 weeks ago. Here's the thread-- https://news.ycombinator.com/item?id=16101072
A note about one of the comments there related to Aspirin, namely, this one:
https://news.ycombinator.com/item?id=16102328
There's an alternative solution for the stomach lining issue:
https://en.wikipedia.org/wiki/Carbasalate_calcium
Which reminds me, this testicle study seems to fail to distinguish Dex(tro)ibuprofen from Levoibuprofen. That seems rather disappointing, as we've known about the difference between the two for quite a while.
This continued ignorance of medical science when it comes to (stereo)isomers never ceases to amaze me. I mean... You'd think they'd have learned their lessons by now.
(Then again, we also still fail to employ multi-compartment models of pharmacology in the vast majority of studies. And... ugh. I'll avoid ranting on how shitty medical science seems to me and just leave it at this.)
[btw., if you wonder why you can't get your hands on Dexibuprofen in the US:
"Open committee discussion. The committees will discuss new drug application (NDA) 20–373, S+ Ibuprofen (dexibuprofen, Sterling Winthrop/ Bayer) 200-milligram caplet, indicated for the temporary relief of minor aches and pains associated with the common cold, headache, toothache, muscular aches, back ache, menstrual cramps, minor pain of arthritis, and for the temporary reduction of fever for OTC status." From the Federal Register, from 1996. It never got approved, and one can't even find the application on the FDA page, thus one can't find out more about why it never made it to market!]
Re: Ibuprofen alters human testicular physiology including testosterone production
#66Earlier quoted context omitted.
Are there any good numbers on the fertility among people who actually WANT to conceive, rather than the raw total population rates (which is affected by people who don't want kids - prevented through birth control and abortions)
"One 2012 report, which presented the results of the study of over 26,000 French men, showed that the sperm count had fallen by a third between 1989 and 2005. A 2007 report in the UK presented the results of a study done on one city in the country. It showed that sperm counts had declined by over 29 percent between 1989 and 2002. And more recently, in the summer of 2017, a study by scientists at the Hebrew University…
Not what GP was asking. Desire might not even correlate with sperm count!
Maybe decreased desire even leads to count and motility decreases?
Re: Ibuprofen alters human testicular physiology including testosterone production
#67This isn't really huge news, technically speaking. Any anti-inflammatory drug will have negative net impact on your body function. For a while we know now that NSAIDs alter ROS levels in response to injury and in fact any normal process. NSAIDs also have negative impact on training adaptation or cell death due to overexpression of ROS. So no - taking overabundant levels of oral NSAIDs isn't going to be good for you a…
The energy drink makers have been trying to defend the use of taurine in their ingredients for a long time. This looks like a golden opportunity for them....
Probably, not so much. The amounts of ingredients and composition of ingredients in energy drinks are just stupid. I see now a trend of "health" drinks that actually seem sensible, though a bit more pricey. Like magnesium, ginseng and vitamins.
The problem with energy drinks is that they're alike to a bottle of all things that may be fuel, combined. I've seen recently a tin of Monster that had 0.5g of caffeine. That's insane. And caffeine pills are even more insane. You can drop 1g of caffeine like it's M&Ms.
At this rate we're going to have coke and amphetamine in those next year. And, you know, you can go on a limb and say that some of the modified amphetamines or phenidatess or what not maybe should be on the market. In Canada they have effedrine in OTC supplements and people don't die from overdose.
But the thing is, we either demonise or just assume something is safe. How many people knows that acetaminophen (APAP, paracetamol) is liver toxic? And how many people knows that NAC is the antidote (N-acetylo-cysteine, popular OTC expectorant)?